Gewebebiomechanik und Mechanobiologie

2022

  1. Adamo CS, Beyens A, Schiavinato A, Keene DR, Tufa SF, Mörgelin M, Brinckmann J, Sasaki T, Niehoff A, Dreiner M, Pottie L, Mosquera LM, Gulec EY, Gezdirici A, Bonaldo P, Wagener R, Paulsson M, Bornaun H, De Rycke R, De Bruyne M, Baeke F, Devine WP, Gangaram B, Tam A, Balasubramanian M, Ellard S, Moore S, Symoens S, Shen J, Cole S, Holmes KW, Hayflick SJ, Nampoothiri S, Davis E, Sakai LY, Sengle G, Callewaert B (2022). EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis. American Journal of Human Genetics 109(12):2230-2252.
  2. Georgieva VS, Bluhm B, Probst K, Zhu M, Heilig J, Niehoff A, Brachvogel B (2022). Ablation of the miRNA cluster 24 in cartilage impairs bone remodeling. Scientific Reports 12(1):9116.
  3. Dreiner M, Munk T, Zaucke F, Liphardt AM, Niehoff A (2022). Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individuals. Scientific Reports 12(1):6434.
  4. Prasse T, Stratos I, Niehoff A, Christ H, Heck V, Meyer C, Mittlmeier T (2022). Bisphenol A-Related Effects on Bone Morphology and Biomechanical Properties in an Animal Model. Toxics 14;10(2):86.
  5. Morcos YAT, Lütke S, Tenbieg A, Hanisch FG, Pryymachuk G, Piekarek N, Hoffmann T, Keller T, Janoschek R, Niehoff A, Zaucke F, Dötsch J, Hucklenbruch-Rother E, Sengle G (2022). Sensitive asprosin detection in clinical samples reveals serum/saliva correlation and indicates cartilage as source for serum asprosin. Scientific Reports 12(1):1340.

2021

  1. Welcker D, Stein C, Feitosa NM, Armistead J, Zhang JL, Lütke S, Kleinridders A, Brüning JC, Eming SA, Sengle G, Niehoff A, Bloch W, Hammerschmidt M (2021). Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions. Scientific Report 11(1):17926.
  2. Weber M, Rothschild MA, Niehoff A (2021). Anisotropic and age-dependent elastic material behavior of the human costal cartilage. Scientific Report 11(1):13618.
  3. Wolff L, Strathmann EA, Müller I, Mählich D, Veltmann C, Niehoff A, Wirth B (2021). Plastin 3 in health and disease: a matter of balance. Cellular and Molecular Life Sciences 78(13):5275-5301.
  4. Weber M, Niehoff A, Rothschild MA (2021). Insights to enhance the examination of tool marks in human cartilage. International Journal of Legal Medicine 135(5):2117-2134.
  5. Mählich D, Glasmacher A, Müller I, Oppermann J, Grevenstein D, Eysel P, Heilig J, Wirth B, Zaucke F, Niehoff A (2021). Expression and localization of thrombospondins, plastin 3, and STIM1 in different cartilage compartments of the osteoarthritic varus knee. International Journal of Molecular Sciences 22, 3073.
  6. Imhof T, Balic A, Heilig J, Chiquet-Ehrismann R, Chiquet M, Niehoff A, Brachvogel B, Thesleff I, Koch M (2021). Pivotal role of tenascin-W (-N) in postnatal incisor growth and periodontal ligament remodeling. Frontiers in Immunology 11:608223.
  7. Seifer P,  Hay E, Fleischhauer L, Heilig J, Bloch W, Sonntag S, Aszodi A, Niehoff A, Cohen-Solal M, Paulsson M, Wagener R, Zaucke F (2021). The matrilin-3 T298M mutation predisposes for osteoarthritis in a knock-in mouse model. Osteoarthritis and Cartilage 29(1):78-88.

2020

  1. Schönborn K, Willenborg S, Schulz JN, Imhof T, Quondamatteo F, Brinckmann J, Niehoff A, Koch M, Eckes B, Kriega T (2020). Role of collagen XII in skin homeostasis and repair. Matrix Biology 94:57-76.
  2. Liphardt AM, Bolte V, Eckstein F, Wirth W, Brüggemann GP, Niehoff A (2020). Thigh muscle anatomical cross-sectional area measured by MRI: regional sensitivity to 21 days of head-down tilt bed rest and the effectiveness of training and nutrition countermeasures. Translational Sports Medicine 3:93–106.
  3. Grevenstein D, Heilig J, Dargel J, Oppermann J, Eysel P, Brochhausen C, Niehoff A (2020). COMP in the infrapatellar fat pad - results of a prospective histological, immunohistological and biochemical case-control study. Journal of Orthopaedic Research 38(4):747-758.
  4. Firner S, Zaucke F, Heilig J, de Marées M, Willwacher S, Brüggemann GP, Niehoff A (2019). Impact of knee joint loading on fragmentation of serum cartilage oligomeric matrix protein (COMP). Journal of Orthopaedic Research 38(8):1710-1718.
  5. Li P, Fleischhauer L, Nicolae C, Prein C, Farkas Z, Saller MM, Prall WC, Wagener R, Heilig J, Niehoff A, Clausen-Schaumann H, Alberton P, Aszodi A (2020). Mice lacking the matrilin family of extracellular matrix proteins develop mild skeletal abnormalities and are susceptible to age-associated osteoarthritis. International Journal of Molecular Science 19;21(2).
  6. Kramer A, Kümmel J, Dreiner M, Willwacher S, Frett T, Niehoff A, Gruber M (2020). Adaptability of a jump movement pattern to a non-constant force field elicited via centrifugation. PLoS One 15(4):e0230854.
  7. Heilig J, Dietmar HF, Brachvogel B, Paulsson P, Zaucke F, Niehoff A (2020). Collagen IX deficiency leads to premature vascularization and ossification of murine femoral heads through an imbalance of pro- and antiangiogenic factors. Osteoarthritis and Cartilage 28(7):988-999.
  8. Liphardt AM, Mündermann A, Heer M, Achtzehn S, Niehoff A, Mester J (2020). Locomotion replacement exercise cannot counteract cartilage biomarker response to 5 days of immobilization in healthy adults Journal of Orthopaedic Research 38(11):2373-2382.
  9. Dreiner M, Willwacher S, Kramer A, Kümmel J, Frett T, Zaucke F, Liphardt AM, Gruber M, Niehoff A (2020). Short-term response of serum cartilage oligomeric matrix protein (COMP) to different types of impact loading under normal and artificial gravity. Frontiers in Physiology 11:1032.

2019

  1. Stoffel W, Hammels I, Jenke B, Schmidt-Soltau I, Niehoff A (2019). Neutral sphingomyelinase 2 (SMPD3)-deficiency in mice causes chondrodysplasia with unimpaired skeletal mineralization. American Journal of Pathology 189(9):1831-1845.
  2. Holzer T, Probst K, Etich J, Auler M, Georgieva VS, Bluhm B, Frie C, Heilig J, Niehoff A, Nüchel J, Plomann M, Seeger JM, Kashkar H, Baris OR, Wiesner RJ, Brachvogel B (2019). Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases. Journal of Cell Biology 218(6):1853-187.

2018

  1. Neugebauer J, Heilig J, Hosseinibarkooie S, Ross BC, Mendoza-Ferreira N, Nolte F, Peters M, Hölker I, Hupperich K, Tschanz T, Grysko V, Zaucke F, Niehoff A, Wirth B (2018). Plastin 3 influences bone homeostasis through regulation of osteoclast activity. Human Molecular Genetics 27(24):4249-4262.
  2. Probst K, Stermann J, von Bomhard I, Etich J, Pitzler L, Niehoff A, Bluhm B, Xu HC, Lang PA, Chmielewski M, Abken H, Blissenbach B, Machova A, Papadopoulou N, Brachvogel B (2018). Depletion of collagen IX alpha1 impairs myeloid cell function. Stem Cells 36(11):1752-1763.
  3. Firner S, Willwacher S, de Marées M, Bleuel J, Zaucke F, Brüggemann GP, Niehoff A (2018). Effect of increased mechanical knee joint loading during running on the serum concentration of cartilage oligomeric matrix protein (COMP). Journal of Orthopaedic Research 36(7):1937-1946.
  4. Zheng W, Rogoschin J, Niehoff A, Oden K, Kulling SE, Xie M, Diel P (2018). Combinatory effects of phytoestrogens and exercise on body fat mass and lipid metabolism in ovariectomized female rats. Journal of Steroid Biochemistry and Molecular Biology178:73-81.

2017

  1. Firner S, Zaucke F, Michael J, Dargel J, Schiwy-Bochat K-H, Heilig J, Rothschild MA, Eysel P, Brüggemann G-P, Niehoff A (2017). Extracellular distribution of collagen II and perifibrillar adapter proteins in healthy and osteoarthritic human knee joint cartilage. Journal of Histochemistry and Cytochemistry 65(10):593-606.
  2. Bluhm B, Ehlen HWA, Holzer T, Georgieva VS, Heilig J, Pitzler L, Etich J, Bortecen T, Frie C, Probst K, Niehoff A, Belluoccio D, Van den Bergen J, Brachvogel B (2017). miR-322 stabilizes MEK1 expression to inhibit RAF/MEK/ERK pathway activation in cartilage. Development 144(19):3562-3577.
  3. Oswald I, Rickert M, Brüggemann G-P, Niehoff A, Fonseca Ulloa CA, Jahnke A (2017). The influence of cryopreservation and quick-freezing on the mechanical properties of tendons. Journal of Biomechanics 64:226-230.

2016

  1. Zigrino P, Brinkmann J, Niehoff A, Lu Y, Giebeler N, Eckes B, Kadler KE, Mauch C (2016). Fibroblast-derived MMP-14 regulates collagen homeostasis in adult skin. Journal of Investigative Dermatology 136(8):1575-83.
  2. Schulz JN, Nüchel J, Niehoff A, Bloch W, Schönborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F, Eckes B (2016). COMP-assisted collagen secretion - a novel intracellular function required for the development of fibrosis. Journal of Cell Science 129(4):706-716.
  3. Kamper M, Hamann N, Prein C, Clausen-Schaumann H, Farkas Z, Aszodi A, Niehoff A, Paulsson M, Zaucke F (2016). Early changes in morphology, bone mineral density and matrix composition of vertebrae lead to disc degeneration in aged collagen IX -/- mice. Matrix Biology 49:132-143.
  4. Müller DR, Basso F, Kurrat A, Soukup ST, Niehoff A, Kulling SE, Diel P (2016). Dose-dependent effects of isoflavone exposure during early lifetime on development and androgen sensitivity in male Wistar rats. Molecular Nutrition & Food Research 60(2):325-336.
  5. Spies CK, Niehoff A, Unglaub F, Müller LP, Langer MF, Hahn P, Oppermann J (2016). Biomechanical comparison of transosseous re-fixation of the deep fibres of the distal radioulnar ligaments versus deep and superficial fibres: a cadaver study. International Orthopaedics 40(2):315-321.

2015

  1. KnipperJA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA (2015). Interleukin-4 receptor α signaling in myeloid cells controls collagen fibril assembly in skin repair. Immunity 43(4):803-816.
  2. Bleuel J, Zaucke F, Brüggemann G-P, Heilig J, Wolter ML, Hamann N, Firner S, Niehoff A (2015). Moderate cyclic tensile strain alters the assembly of cartilage extracellular matrix proteins in vitro. Journal of Biomechanical Engineering 137(6):061009.
  3. Bleuel J, Zaucke F, Brüggemann G-P, Niehoff A (2015). Effects of cyclic tensile strain on chondrocyte metabolism: a systematic review. PLoS One 30;10(3):e0119816.
  4. Schulz JN, Zeltz C, Sørensen IW, Barczyk M, Carracedo S, Hallinger R, Niehoff A, Eckes B, Gullberg D (2015). Reduced granulation tissue and wound strength in the absence of α11β1 integrin. Journal of Investigative Dermatology 135(5):1435-1444.

2014

  1. Lettmann S, Bloch W, Maaß T, Niehoff A, Schulz JN, Eckes B, Eming SA, Bonaldo P, Paulsson M, Wagener R (2014). Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies: expression of classical and novel collagen VI variants during wound healing. PLoS One 26;9(8):e105686.
  2. Hamann N, Zaucke F, Heilig J, Oberländer KD, Brüggemann GP, Niehoff A (2014). Effect of different running modes on the morphological, biochemical, and mechanical properties of articular cartilage. Scandinavian Journal of Medicine and Science in Sport 24(1): 179-188.
  3. Karamanidis K, Oberländer KD, Niehoff A, Epro G, Brüggemann G.-P. (2014). Effect of exercise-induced enhancement of the leg-extensor muscle-tendon unit capacities on ambulatory mechanics and knee osteoarthritis markers in the elderly. PLoS One 6;9(6):e99330.
  4. Hamann N, Brüggemann G-P, Niehoff A (2014). Topographical variations in articular cartilage and subchondral bone of the normal rat knee are age-related. Annals of Anatomy 196(5): 278-285.
  5. Niehoff A, Lechner P, Ratiu O, Reuter S, Hamann N, Brüggemann GP, Schönau E, Bloch W, Beccard R (2014). Effect of whole body-vibration and insulin-like growth factor-I (IGF-I) on muscle paralysis-induced bone degeneration after botulinum toxin injection in mice. Calcified Tissue International 94(4): 373-383.

2013

  1. Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PL, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V (2013). Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasis-like arthritis. Arthritis and Rheumatism 65(9): 2290 2300.
  2. Rui Y, Subic A, Takla M, Wang CH, Niehoff A, Hamann N, Brueggemann GP (2013). Biomimetic design of lightweight vehicle structures based on animal bone properties. Advanced Materials Research 633: 3-14.
  3. Hamann N, Zaucke F, Dayakli M, Brüggemann GP, Niehoff A (2013). Growth-related structural, biochemical, and mechanical properties of the functional bone-cartilage unit. Journal of Anatomy 222(2): 248-259.

2012

  1. Grskovic I, Kutsch A, Frie C, Groma G, Stermann J, Schlötzer-Schrehardt U, Niehoff A, Moss SE, Rosenbaum S, Pöschl E, Chmielewski M, Rappl G, Abken H, Bateman JF, Cheah KS, Paulsson M, Brachvogel B (2012). Depletion of annexin A5, annexin A6 and collagen X causes no gross changes in matrix vesicle mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response. Journal of Bone and Mineral Research 27 (11): 2399 2412.
  2. Hamann N, Kohler T, Müller R, Brüggemann GP, Niehoff A (2012). The effect of level and downhill running on cortical and trabecular bone in growing rats. Calcified Tissue International 90(5): 429-437.
  3. Groma G, Xin W, Grskovic I, Niehoff A, Brachvogel B, Paulsson M, Zaucke F (2012). Abnormal bone quality in cartilage oligomeric matrix protein and matrilin-3 double deficient mice caused by increased tissue inhibitor of metalloproteinases-3 deposition and delayed aggrecan degradation. Arthritis and Rheumatism 64(8): 2644 2654.
  4. Blumbach K*, Niehoff A*, Belgardt BF, Ehlen HW, Schmitz M, Hallinger R, Schulz JN, Brüning JC, Krieg T, Schubert M, Gullberg D, Eckes B (2012). Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels. Journal of Biological Chemistry 287(9): 6431 6440 (*both authors contributed equally).

2011

  1. Niehoff A, Müller M, Brüggemann L, Savage T, Zaucke F, Eckstein F, Müller-Lung U, Brüggemann G-P (2011). Deformational behaviour of knee cartilage and changes in serum cartilage oligomeric matrix protein (COMP) after running and drop landing. Osteoarthritis and Cartilage 19(8): 1003 1010.
  2. Brüggemann G-P, Niehoff A (2011). Tissue response to impact loading in sports. Portugese Journal of Sport Science 11(Suppl. 2): 11-17.
  3. Brüggemann G-P, Brüggemann L, Heinrich K, Müller M, Niehoff A (2011). Biological tissue response to impact like mechanical loading. Footwear Science 3: 13-22.
  4. Baur A, Henkel J, Bloch W, Treiber N, Scharffetter-Kochanek K, Brüggemann GP, Niehoff A (2011). Effect of exercise on bone and articular cartilage in heterozygous manganese superoxide dismutase (SOD2) deficient mice. Free Radical Research 45(5): 550-558.

2010

  1. Niehoff A, Kersting UG, Helling S, Dargel J, Maurer J, Thevis M, Brüggemann GP (2010). Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans. European Journal of Applied Physiology 110(3): 651-657.
  2. Belluoccio D, Grskovic I, Niehoff A, Schlötzer-Schrehardt U, Rosenbaum S, Etich J, Frie C, Pausch F, Moss SE, Pöschl E, Bateman JF, Brachvogel B (2010). Deficiency of annexins 5 and 6 induces complex changes in the transcriptome of growth plate cartilage, but does not inhibit the induction of mineralization. Journal of Bone and Mineral Research 25(1): 141-153.

2009

  1. Popken F, Michael JW, Zarghooni K, Sobottke R, Kasper HU, Blaecker D, Niehoff A, Emrich F, Eysel P (2009). Stability changes after cryosurgery in long tubular bones in correlation to histological results: an animal trial. Archives of Orthopaedic and Trauma Surgery 129(6): 857-862.

2008

  1. Blumbach K, Niehoff A, Paulsson M, Zaucke F (2008). Ablation of collagen IX and COMP disrupts epiphyseal cartilage architecture. Matrix Biology 27(4): 306-318.
  2. Niehoff A, Offermann M, Dargel J, Schmidt A, Brüggemann G-P, Bloch W (2008). Static and dynamic mechanical compression affects Akt phosphorylation in porcine patellofemoral joint cartilage. Journal of Orthopaedic Research 26(5): 616-623.
  3. Schmitz M, Niehoff A, Miosge N, Smyth N, Paulsson M, Zaucke F (2008). Transgenic mice expressing D469Delta mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformations. Matrix Biology 27(2): 67-85.

2007

  1. Södersten F, Ekman S, Niehoff A, Zaucke F, Heinegård D, Hultenby K (2007). Ultrastructural immunolocalization of cartilage oligomeric matrix protein (COMP), thrombospondin-4 (TSP-4) and collagen fibril size in the rodent achilles tendon in relation to exercise. Connective Tissue Research 48(5): 254-262.
  2. Stoffel W, Jenke B, Holz B, Binczek E, Günter RH, Knifka J, Koebke J, Niehoff A (2007). Neutral sphingomyelinase (SMPD3) deficiency causes a novel form of chondrodysplasia and dwarfism that is rescued by Col2A1-driven smpd3 transgene expression. American Journal of Pathology 171(1): 153-161.
  3. Nicolae C, Ko YP, Miosge N, Niehoff A, Studer D, Hunziker EB, Paulsson M, Wagener R, Aszodi A (2007). Abnormal collagen fibrils in cartilage of matrilin-1/matrilin-3-deficient mice. Journal of Biological Chemistry 282(30): 22163 22175.
  4. Legerlotz K, Schjerling P, Langberg H, Brüggemann G-P, Niehoff A (2007). The effect of running, strength and vibration strength training on the mechanical, morphological and biochemical properties of the Achilles tendon in rats. Journal of Applied Physiology 102(2): 564-572.

2004

  1. Niehoff A, Kersting UG, Zaucke F, Morlock MM, Brüggemann G-P (2004). Adaptation of mechanical, morphological, and biochemical properties of the rat growth plate to dose-dependent voluntary exercise. Bone 35(4): 899-908.     
  2. Popken F, Niehoff A, Emrich F, Blaecker D, Bosse M, Michael J, Brüggemann G-P, Eysel P (2004). Stabilitätsveränderungen nach kryochirurgischer Behandlung an langen Röhrenknochen. Unfallchirurg 107(2): 113-137.