RAD140 - Selective Androgen Receptor Modulator (SARM)
RAD140 was first referred to as a new drug entity with SARM-like properties in 2011 by Miller et al.:
Miller CP, Shomali M, Lyttle CR, O'Dea LS, Herendeen H, Gallacher K, Paquin D, Compton DR, Sahoo B, Kerrigan SA, Burge MS, Nickels M, Green JL, Katzenellenbogen JA, Tchesnokov A, Hattersley G. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2011 Feb 10; 2(2):124-9.
Abstract and free Article
In 2013 the first method for the detection of the illegal use of RAD140 in sport was published:
Mario Thevis, Thomas Piper, Simon Beuck, Hans Geyer and Wilhelm Schänzer. Expanding sports drug testing assays: Mass spectrometric characterization of the selective androgen receptor modulator drug candidates RAD140 and ACP-105 Rapid Commun. Mass Spectrom. 2013, 27, 1173–1182.
In the following publications the identification of a SARM-based substance RAD140 distributed via Internet is reported:
Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet. JAMA. 2017 Nov 28;318(20):2004-2010.
Abstract and free article
Krug O, Thomas A, Walpurgis K, Piper T, Laußmann T, Röder R, Thevis M: Black market products suspected to contain doping relevant ingredients - annual report for 2017. In: Thevis M, Geyer H, Mareck U (eds.) Recent advances in doping analysis (26). Sportverlag Strauß, Köln (2018) 76 81.
Krug O , Thomas A , Walpurgis K , Piper T , Geyer H , Thevis M: Black market products suspected to contain doping relevant ingredients - annual report for 2018. In: Thevis M, Geyer H, Mareck U (eds.) Recent advances in doping analysis (27). Sportverlag Strauß, Köln (2019) 98 102.
The first two positive doping control samples proofing the abuse of RAD140 were reported by the World Anti-Doping Agency (WADA) in 2016.
see also WADA statistics for SARMs SARMs