1 Prohibited Substances ANABOLIC AGENTS • Compounds boldenone, boldione, 19-norandrostenedione, and nandrolone have been transferred and 19-norandrostenediol added to the S1.b section because they can be produced endogenously at low concentrations. This change does not affect the prohibited status of these substances. The interpretation and reporting of findings for these substances is addressed in specific Technical Documents (TD2016IRMS and/or TD2016NA). • 5α-androst-2-ene-17-one, commonly known as “Delta-2” or 2-androstenone, was added as an example of metabolite of DHEA, more recently found in dietary supplements. PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES AND MIMETICS • To extend the scope of Erythropoietic Stimulating Agents, GATA inhibitors (e.g. K-11706) and Transforming Growth Factor- β (TGF-β) inhibitors (e.g. sotatercept, luspatercept) were added. • The International Nonproprietary Name (INN) of FG-4592, roxadustat, was added. • Molidustat was added as another example of HIF stabilizer. • Cobalt: It is re-iterated that vitamin B12, which contains cobalt, is not prohibited. S1 S2 BETA-2-AGONISTS • The reference to isomers was simplified. • Examples of selective and non-selective beta-2-agonists were added (fenoterol, formoterol, higenamine, indacaterol, olodaterol, procaterol, reproterol, salbutamol, salmeterol, terbutaline, vilanterol). • Higenamine is documented to be a constituent of the plant Tinospora crispa, which can be found in some dietary supplements and is a non-selective beta-2-agonist. • Dosing parameters of salbutamol were refined to make it clear that the full 24 hour dose should not be administered at one time. • The maximum dosage for salmeterol was stated according to the manufacturers’ recommendations. • Studies are ongoing to establish an appropriate urinary threshold concentration for inhaled salmeterol. At present, the Technical Document TD2015MRPL recommends not to report salmeterol below 10 ng/mL. HORMONE AND METABOLIC MODULATORS • Androsta-3,5-diene-7,17-dione (arimistane) was added as a new example of aromatase inhibitor. Prohibited Methods MANIPULATION OF BLOOD AND BLOOD COMPONENTS • Supplemental oxygen administered by inhalation, but not intravenously, is permitted. To clarify this, M1.2 now reads “excluding supplemental oxygen by inhalation”. S3 S4 M1 SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES 2017 PROHIBITED LIST Substances and methods prohibited at all times (In- and Out-of-Competition) 2 Substances and Methods Prohibited In-Competition STIMULANTS • Lisdexamfetamine was added to S6.a; it is an inactive pro-drug of amfetamine. • In the absence of an INN for methylhexaneamine, its International Union of Pure and Applied Chemistry (IUPAC) name, 4-methylhexan-2-amine, was added. A number of other synonyms exist for methylhexaneamine including: 1,3-dimethylamylamine, dimethylpentylamine; methylhexamine; methylhexanamine; 1,3-dimethylpentylamine. • Regular food consumption will not yield sufficient levels of phenylethylamine to result in an Adverse Analytical Finding. NARCOTICS • Nicomorphine was added. It is an opioid analgesic drug, which is converted to morphine following administration. GLUCOCORTICOIDS • After consideration of stakeholders’ comments, no changes were made in this section for 2017. S6 S7 S9 MONITORING PROGRAM The following were added to establish patterns of use: • Codeine; • Concurrent use of multiple beta-2-agonists.

1 Prohibited Substances ANABOLIC AGENTS • Compounds boldenone, boldione, 19-norandrostenedione, and nandrolone have been transferred and 19-norandrostenediol added to the S1.b section because they can be produced endogenously at low concentrations. This change does not affect the prohibited status of these substances. The interpretation and reporting of findings for these substances is addressed in specific Technical Documents (TD2016IRMS and/or TD2016NA). • 5α-androst-2-ene-17-one, commonly known as “Delta-2” or 2-androstenone, was added as an example of metabolite of DHEA, more recently found in dietary supplements. PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES AND MIMETICS • To extend the scope of Erythropoietic Stimulating Agents, GATA inhibitors (e.g. K-11706) and Transforming Growth Factor- β (TGF-β) inhibitors (e.g. sotatercept, luspatercept) were added. • The International Nonproprietary Name (INN) of FG-4592, roxadustat, was added. • Molidustat was added as another example of HIF stabilizer. • Cobalt: It is re-iterated that vitamin B12, which contains cobalt, is not prohibited. S1 S2 BETA-2-AGONISTS • The reference to isomers was simplified. • Examples of selective and non-selective beta-2-agonists were added (fenoterol, formoterol, higenamine, indacaterol, olodaterol, procaterol, reproterol, salbutamol, salmeterol, terbutaline, vilanterol). • Higenamine is documented to be a constituent of the plant Tinospora crispa, which can be found in some dietary supplements and is a non-selective beta-2-agonist. • Dosing parameters of salbutamol were refined to make it clear that the full 24 hour dose should not be administered at one time. • The maximum dosage for salmeterol was stated according to the manufacturers’ recommendations. • Studies are ongoing to establish an appropriate urinary threshold concentration for inhaled salmeterol. At present, the Technical Document TD2015MRPL recommends not to report salmeterol below 10 ng/mL. HORMONE AND METABOLIC MODULATORS • Androsta-3,5-diene-7,17-dione (arimistane) was added as a new example of aromatase inhibitor. Prohibited Methods MANIPULATION OF BLOOD AND BLOOD COMPONENTS • Supplemental oxygen administered by inhalation, but not intravenously, is permitted. To clarify this, M1.2 now reads “excluding supplemental oxygen by inhalation”. S3 S4 M1 SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES 2017 PROHIBITED LIST Substances and methods prohibited at all times (In- and Out-of-Competition) 2 Substances and Methods Prohibited In-Competition STIMULANTS • Lisdexamfetamine was added to S6.a; it is an inactive pro-drug of amfetamine. • In the absence of an INN for methylhexaneamine, its International Union of Pure and Applied Chemistry (IUPAC) name, 4-methylhexan-2-amine, was added. A number of other synonyms exist for methylhexaneamine including: 1,3-dimethylamylamine, dimethylpentylamine; methylhexamine; methylhexanamine; 1,3-dimethylpentylamine. • Regular food consumption will not yield sufficient levels of phenylethylamine to result in an Adverse Analytical Finding. NARCOTICS • Nicomorphine was added. It is an opioid analgesic drug, which is converted to morphine following administration. GLUCOCORTICOIDS • After consideration of stakeholders’ comments, no changes were made in this section for 2017. S6 S7 S9 MONITORING PROGRAM The following were added to establish patterns of use: • Codeine; • Concurrent use of multiple beta-2-agonists.

THE WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2017 The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. This List shall come into effect on 1 January 2017 2 IN ACCORDANCE WITH ARTICLE 4.2.2 OF THE WORLD ANTI-DOPING CODE, ALL PROHIBITED SUBSTANCES SHALL BE CONSIDERED AS “SPECIFIED SUBSTANCES” EXCEPT SUBSTANCES IN CLASSES S1, S2, S4.4, S4.5, S6.A, AND PROHIBITED METHODS M1, M2 AND M3. PROHIBITED SUBSTANCES SUBSTANCES & METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) NON-APPROVED SUBSTANCES Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times. ANABOLIC AGENTS Anabolic agents are prohibited. 1. ANABOLIC ANDROGENIC STEROIDS (AAS) a. Exogenous* AAS, including: 1-Androstenediol (5α-androst-1-ene-3β,17β-diol); 1-Androstenedione (5α-androst-1-ene-3,17-dione); 1-Testosterone (17β-hydroxy-5α-androst-1-en-3-one); 4-Hydroxytestosterone (4,17β-dihydroxyandrost-4-en-3-one); Bolandiol (estr-4-ene-3β,17β-diol); Bolasterone; Calusterone; Clostebol; Danazol ([1,2]oxazolo[4',5':2,3]pregna-4-en-20-yn-17α-ol); Dehydrochlormethyltestosterone (4-chloro-17β-hydroxy- 17α-methylandrosta-1,4-dien-3-one); Desoxymethyltestosterone (17α-methyl-5α-androst- 2-en-17β-ol); Drostanolone; Ethylestrenol (19-norpregna-4-en-17α-ol); Fluoxymesterone; Formebolone; Furazabol (17α-methyl [1,2,5]oxadiazolo[3',4':2,3]-5α- androstan-17β-ol); Gestrinone; S0 S1 Mestanolone; Mesterolone; Metandienone (17β-hydroxy-17α-methylandrosta-1,4-dien- 3-one); Metenolone; Methandriol; Methasterone (17β-hydroxy-2α,17α-dimethyl-5α- androstan-3-one); Methyldienolone (17β-hydroxy-17α-methylestra-4,9-dien- 3-one); Methyl-1-testosterone (17β-hydroxy-17α-methyl-5α- androst-1-en-3-one); Methylnortestosterone (17β-hydroxy-17α-methylestr-4-en- 3-one); Methyltestosterone; Metribolone (methyltrienolone, 17β-hydroxy-17α- methylestra-4,9,11-trien-3-one); Mibolerone; Norboletone; Norclostebol; Norethandrolone; Oxabolone; Oxandrolone; Oxymesterone; Oxymetholone; Prostanozol (17β-[(tetrahydropyran-2-yl)oxy]-1'H- pyrazolo[3,4:2,3]-5α-androstane); Quinbolone; Stanozolol; Stenbolone; Tetrahydrogestrinone (17-hydroxy-18a-homo-19-nor-17α- pregna-4,9,11-trien-3-one); Trenbolone (17β-hydroxyestr-4,9,11-trien-3-one); and other substances with a similar chemical structure or similar biological effect(s). 3 b. Endogenous** AAS when administered exogenously: 19-Norandrostenediol (estr-4-ene-3,17-diol); 19-Norandrostenedione (estr-4-ene-3,17-dione); Androstenediol (androst-5-ene-3β,17β-diol); Androstenedione (androst-4-ene-3,17-dione); Boldenone; Boldione (androsta-1,4-diene-3,17-dione); Dihydrotestosterone (17β-hydroxy-5α-androstan-3-one); Nandrolone (19-nortestosterone); Prasterone (dehydroepiandrosterone, DHEA, 3β-hydroxyandrost-5-en-17-one); Testosterone; and their metabolites and isomers, including but not limited to: 3β-Hydroxy-5α-androstan-17-one; 5α-Androst-2-ene-17-one; 5α-Androstane-3α,17α-diol; 5α-Androstane-3α,17β-diol; 5α-Androstane-3β,17α-diol; 5α-Androstane-3β,17β-diol; 5β-Androstane-3α,17β-diol; 7α-Hydroxy-DHEA; 7β-Hydroxy-DHEA; 4-Androstenediol (androst-4-ene-3β, 17β-diol); 5-Androstenedione (androst-5-ene-3,17-dione); 7-Keto-DHEA; 19-Norandrosterone; 19-Noretiocholanolone; Androst-4-ene-3α,17α-diol; Androst-4-ene-3α,17β-diol; Androst-4-ene-3β,17α-diol; Androst-5-ene-3α,17α-diol; Androst-5-ene-3α,17β-diol; Androst-5-ene-3β,17α-diol; Androsterone; Epi-dihydrotestosterone; Epitestosterone; Etiocholanolone. 2. OTHER ANABOLIC AGENTS Including, but not limited to: • Clenbuterol; • Selective androgen receptor modulators (SARMs, e.g. andarine and ostarine); • Tibolone; • Zeranol; • Zilpaterol. For purposes of this section: * “exogenous” refers to a substance which is not ordinarily produced by the body naturally. ** “endogenous” refers to a substance which is ordinarily produced by the body naturally. PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES, AND MIMETICS The following substances, and other substances with similar chemical structure or similar biological effect(s), are prohibited: 1. Erythropoietin-Receptor agonists: 1.1 Erythropoiesis-Stimulating Agents (ESAs) including e.g. Darbepoietin (dEPO); Erythropoietins (EPO); EPO-Fc; EPO-mimetic peptides (EMP), e.g. CNTO 530 and peginesatide; GATA inhibitors, e.g. K-11706; Methoxy polyethylene glycol-epoetin beta (CERA); Transforming Growth Factor-β (TGF-β) inhibitors, e.g. sotatercept, luspatercept; 1.2 Non-erythropoietic EPO-Receptor agonists, e.g. ARA-290; Asialo EPO; Carbamylated EPO. 2. Hypoxia-inducible factor (HIF) stabilizers, e.g. cobalt, molidustat and roxadustat (FG-4592); and HIF activators, e.g. argon and xenon. S2 4 3. Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) and their releasing factors, e.g. buserelin, gonadorelin and leuprorelin, in males. 4. Corticotrophins and their releasing factors, e.g. corticorelin. 5. Growth Hormone (GH) and its releasing factors including: • Growth Hormone Releasing Hormone (GHRH) and its analogues, e.g. CJC-1295, sermorelin and tesamorelin; • Growth Hormone Secretagogues (GHS), e.g. ghrelin and ghrelin mimetics, e.g. anamorelin and ipamorelin; • GH-Releasing Peptides (GHRPs), e.g. alexamorelin, GHRP-6, hexarelin, and pralmorelin (GHRP-2). Additional prohibited growth factors: Fibroblast Growth Factors (FGFs); Hepatocyte Growth Factor (HGF); Insulin-like Growth Factor-1 (IGF-1) and its analogues; Mechano Growth Factors (MGFs); Platelet-Derived Growth Factor (PDGF); Vascular-Endothelial Growth Factor (VEGF) and any other growth factor affecting muscle, tendon or ligament protein synthesis/degradation, vascularisation, energy utilization, regenerative capacity, or fibre type switching. BETA-2 AGONISTS All selective and non-selective beta-2 agonists, including all optical isomers, are prohibited. Including, but not limited to: Fenoterol; Formoterol; Higenamine; Indacaterol; Olodaterol; Procaterol; Reproterol; Salbutamol; Salmeterol; Terbutaline; Vilanterol. S3 Except: • Inhaled salbutamol: maximum 1600 micrograms over 24 hours, not to exceed 800 micrograms every 12 hours; • Inhaled formoterol: maximum delivered dose of 54 micrograms over 24 hours; • Inhaled salmeterol: maximum 200 micrograms over 24 hours. The presence in urine of salbutamol in excess of 1000 ng/mL or formoterol in excess of 40 ng/mL is presumed not to be an intended therapeutic use of the substance and will be considered as an Adverse Analytical Finding (AAF) unless the Athlete proves, through a controlled pharmacokinetic study, that the abnormal result was the consequence of the use of the therapeutic dose (by inhalation) up to the maximum dose indicated above. HORMONE AND METABOLIC MODULATORS The following hormone and metabolic modulators are prohibited: 1. Aromatase inhibitors including, but not limited to: 4-Androstene-3,6,17 trione (6-oxo); Aminoglutethimide; Anastrozole; Androsta-1,4,6-triene-3,17-dione (androstatrienedione); Androsta-3,5-diene-7,17-dione (arimistane); Exemestane; Formestane; Letrozole; Testolactone. 2. Selective estrogen receptor modulators (SERMs) including, but not limited to: Raloxifene; Tamoxifen; Toremifene. 3. Other anti-estrogenic substances including, but not limited to: Clomiphene; Cyclofenil; Fulvestrant. S4 5 4. Agents modifying myostatin function(s) including, but not limited, to: myostatin inhibitors. 5. Metabolic modulators: 5.1 Activators of the AMP-activated protein kinase (AMPK), e.g. AICAR; and Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists, e.g. GW 1516; 5.2 Insulins and insulin-mimetics; 5.3 Meldonium; 5.4 Trimetazidine. DIURETICS AND MASKING AGENTS The following diuretics and masking agents are prohibited, as are other substances with a similar chemical structure or similar biological effect(s). Including, but not limited to: • Desmopressin; probenecid; plasma expanders, e.g. glycerol and intravenous administration of albumin, dextran, hydroxyethyl starch and mannitol; • Acetazolamide; amiloride; bumetanide; canrenone; chlortalidone; etacrynic acid; furosemide; indapamide; metolazone; spironolactone; thiazides, e.g. bendroflu- methiazide, chlorothiazide and hydrochlorothiazide; triamterene and vaptans, e.g. tolvaptan. Except: • Drospirenone; pamabrom; and ophthalmic use of carbonic anhydrase inhibitors (e.g. dorzolamide, brinzolamide); • Local administration of felypressin in dental anaesthesia. The detection in an Athlete’s Sample at all times or In-Competition, as applicable, of any quantity of the following substances subject to threshold limits: formoterol, salbutamol, cathine, ephedrine, methylephedrine and pseudoephedrine, in conjunction with a diuretic or masking agent, will be considered as an Adverse Analytical Finding (AAF) unless the Athlete has an approved Therapeutic Use Exemption (TUE) for that substance in addition to the one granted for the diuretic or masking agent. S5 PROHIBITED METHODS MANIPULATION OF BLOOD AND BLOOD COMPONENTS The following are prohibited: 1. The Administration or reintroduction of any quantity of autologous, allogenic (homologous) or heterologous blood, or red blood cell products of any origin into the circulatory system. 2. Artificially enhancing the uptake, transport or delivery of oxygen. Including, but not limited to: Perfluorochemicals; efaproxiral (RSR13) and modified haemoglobin products, e.g. haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen by inhalation. 3. Any form of intravascular manipulation of the blood or blood components by physical or chemical means. CHEMICAL AND PHYSICAL MANIPULATION The following are prohibited: 1. Tampering, or Attempting to Tamper, to alter the integrity and validity of Samples collected during Doping Control. Including, but not limited to: Urine substitution and/or adulteration, e.g. proteases. 2. Intravenous infusions and/or injections of more than 50 mL per 6 hour period except for those legitimately received in the course of hospital admissions, surgical procedures or clinical investigations. GENE DOPING The following, with the potential to enhance sport performance, are prohibited: 1. The transfer of polymers of nucleic acids or nucleic acid analogues. 2. The use of normal or genetically modified cells. M1 M2 M3 6 IN ADDITION TO THE CATEGORIES S0 TO S5 AND M1 TO M3 DEFINED ABOVE, THE FOLLOWING CATEGORIES ARE PROHIBITED IN-COMPETITION: SUBSTANCES & METHODS PROHIBITED IN-COMPETITION PROHIBITED SUBSTANCES STIMULANTS All stimulants, including all optical isomers, e.g. d- and l- where relevant, are prohibited. Stimulants include: a: Non-Specified Stimulants: Adrafinil; Amfepramone; Amfetamine; Amfetaminil; Amiphenazole; Benfluorex; Benzylpiperazine; Bromantan; Clobenzorex; Cocaine; Cropropamide; Crotetamide; Fencamine; Fenetylline; Fenfluramine; Fenproporex; Fonturacetam [4-phenylpiracetam (carphedon)]; Furfenorex; Lisdexamfetamine; Mefenorex; Mephentermine; Mesocarb; Metamfetamine(d-); p-methylamphetamine; Modafinil; Norfenfluramine; Phendimetrazine; Phentermine; Prenylamine; Prolintane. A stimulant not expressly listed in this section is a Specified Substance. S6 b: Specified Stimulants. Including, but not limited to: 4-Methylhexan-2-amine (methylhexaneamine); Benzfetamine; Cathine**; Cathinone and its analogues, e.g. mephedrone, methedrone, and α- pyrrolidinovalerophenone; Dimethylamphetamine; Ephedrine***; Epinephrine**** (adrenaline); Etamivan; Etilamfetamine; Etilefrine; Famprofazone; Fenbutrazate; Fencamfamin; Heptaminol; Hydroxyamfetamine (parahydroxyamphetamine); Isometheptene; Levmetamfetamine; Meclofenoxate; Methylenedioxymethamphetamine; Methylephedrine***; Methylphenidate; Nikethamide; Norfenefrine; Octopamine; Oxilofrine (methylsynephrine); Pemoline; Pentetrazol; Phenethylamine and its derivatives; Phenmetrazine; Phenpromethamine; Propylhexedrine; Pseudoephedrine*****; 7 Selegiline; Sibutramine; Strychnine; Tenamfetamine (methylenedioxyamphetamine); Tuaminoheptane; and other substances with a similar chemical structure or similar biological effect(s). Except: • Clonidine; • Imidazole derivatives for topical/ophthalmic use and those stimulants included in the 2017 Monitoring Program*. * Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradrol, and synephrine: These substances are included in the 2017 Monitoring Program, and are not considered Prohibited Substances. ** Cathine: Prohibited when its concentration in urine is greater than 5 micrograms per milliliter. *** Ephedrine and methylephedrine: Prohibited when the concentration of either in urine is greater than 10 micrograms per milliliter. **** Epinephrine (adrenaline): Not prohibited in local administration, e.g. nasal, ophthalmologic, or co-administration with local anaesthetic agents. ***** Pseudoephedrine: Prohibited when its concentration in urine is greater than 150 micrograms per milliliter. NARCOTICS Prohibited: Buprenorphine; Dextromoramide; Diamorphine (heroin); Fentanyl and its derivatives; Hydromorphone; Methadone; Morphine; Nicomorphine; Oxycodone; Oxymorphone; Pentazocine; Pethidine. CANNABINOIDS Prohibited: • Natural, e.g. cannabis, hashish and marijuana, or synthetic Δ9-tetrahydrocannabinol (THC). • Cannabimimetics, e.g. “Spice”, JWH-018, JWH-073, HU-210. GLUCOCORTICOIDS All glucocorticoids are prohibited when administered by oral, intravenous, intramuscular, or rectal routes. S7 S8 S9 8 SUBSTANCES PROHIBITED IN PARTICULAR SPORTS ALCOHOL Alcohol (ethanol) is prohibited In-Competition only, in the following sports. Detection will be conducted by analysis of breath and/or blood. The doping violation threshold is equivalent to a blood alcohol concentration of 0.10 g/L. • Air Sports (FAI) • Automobile (FIA) • Archery (WA) • Powerboating (UIM) P1 BETA-BLOCKERS Beta-blockers are prohibited In-Competition only, in the following sports, and also prohibited Out-of-Competition where indicated. • Archery (WA)* • Automobile (FIA) • Billiards (all disciplines) (WCBS) • Darts (WDF) • Golf (IGF) • Shooting (ISSF, IPC)* • Skiing/Snowboarding (FIS) in ski jumping, freestyle aerials/halfpipe and snowboard halfpipe/big air • Underwater sports (CMAS) in constant-weight apnoea with or without fins, dynamic apnoea with and without fins, free immersion apnoea, Jump Blue apnoea, spearfishing, static apnoea, target shooting, and variable weight apnoea. *Also prohibited Out-of-Competition Including, but not limited to: Acebutolol; Labetalol; Alprenolol; Levobunolol; Atenolol; Metipranolol; Betaxolol; Metoprolol; Bisoprolol; Nadolol; Bunolol; Oxprenolol; Carteolol; Pindolol; Carvedilol; Propranolol; Celiprolol; Sotalol; Esmolol; Timolol. P2 www.wada-ama.org

THE WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2017 The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. This List shall come into effect on 1 January 2017 2 IN ACCORDANCE WITH ARTICLE 4.2.2 OF THE WORLD ANTI-DOPING CODE, ALL PROHIBITED SUBSTANCES SHALL BE CONSIDERED AS “SPECIFIED SUBSTANCES” EXCEPT SUBSTANCES IN CLASSES S1, S2, S4.4, S4.5, S6.A, AND PROHIBITED METHODS M1, M2 AND M3. PROHIBITED SUBSTANCES SUBSTANCES & METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) NON-APPROVED SUBSTANCES Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times. ANABOLIC AGENTS Anabolic agents are prohibited. 1. ANABOLIC ANDROGENIC STEROIDS (AAS) a. Exogenous* AAS, including: 1-Androstenediol (5α-androst-1-ene-3β,17β-diol); 1-Androstenedione (5α-androst-1-ene-3,17-dione); 1-Testosterone (17β-hydroxy-5α-androst-1-en-3-one); 4-Hydroxytestosterone (4,17β-dihydroxyandrost-4-en-3-one); Bolandiol (estr-4-ene-3β,17β-diol); Bolasterone; Calusterone; Clostebol; Danazol ([1,2]oxazolo[4',5':2,3]pregna-4-en-20-yn-17α-ol); Dehydrochlormethyltestosterone (4-chloro-17β-hydroxy- 17α-methylandrosta-1,4-dien-3-one); Desoxymethyltestosterone (17α-methyl-5α-androst- 2-en-17β-ol); Drostanolone; Ethylestrenol (19-norpregna-4-en-17α-ol); Fluoxymesterone; Formebolone; Furazabol (17α-methyl [1,2,5]oxadiazolo[3',4':2,3]-5α- androstan-17β-ol); Gestrinone; S0 S1 Mestanolone; Mesterolone; Metandienone (17β-hydroxy-17α-methylandrosta-1,4-dien- 3-one); Metenolone; Methandriol; Methasterone (17β-hydroxy-2α,17α-dimethyl-5α- androstan-3-one); Methyldienolone (17β-hydroxy-17α-methylestra-4,9-dien- 3-one); Methyl-1-testosterone (17β-hydroxy-17α-methyl-5α- androst-1-en-3-one); Methylnortestosterone (17β-hydroxy-17α-methylestr-4-en- 3-one); Methyltestosterone; Metribolone (methyltrienolone, 17β-hydroxy-17α- methylestra-4,9,11-trien-3-one); Mibolerone; Norboletone; Norclostebol; Norethandrolone; Oxabolone; Oxandrolone; Oxymesterone; Oxymetholone; Prostanozol (17β-[(tetrahydropyran-2-yl)oxy]-1'H- pyrazolo[3,4:2,3]-5α-androstane); Quinbolone; Stanozolol; Stenbolone; Tetrahydrogestrinone (17-hydroxy-18a-homo-19-nor-17α- pregna-4,9,11-trien-3-one); Trenbolone (17β-hydroxyestr-4,9,11-trien-3-one); and other substances with a similar chemical structure or similar biological effect(s). 3 b. Endogenous** AAS when administered exogenously: 19-Norandrostenediol (estr-4-ene-3,17-diol); 19-Norandrostenedione (estr-4-ene-3,17-dione); Androstenediol (androst-5-ene-3β,17β-diol); Androstenedione (androst-4-ene-3,17-dione); Boldenone; Boldione (androsta-1,4-diene-3,17-dione); Dihydrotestosterone (17β-hydroxy-5α-androstan-3-one); Nandrolone (19-nortestosterone); Prasterone (dehydroepiandrosterone, DHEA, 3β-hydroxyandrost-5-en-17-one); Testosterone; and their metabolites and isomers, including but not limited to: 3β-Hydroxy-5α-androstan-17-one; 5α-Androst-2-ene-17-one; 5α-Androstane-3α,17α-diol; 5α-Androstane-3α,17β-diol; 5α-Androstane-3β,17α-diol; 5α-Androstane-3β,17β-diol; 5β-Androstane-3α,17β-diol; 7α-Hydroxy-DHEA; 7β-Hydroxy-DHEA; 4-Androstenediol (androst-4-ene-3β, 17β-diol); 5-Androstenedione (androst-5-ene-3,17-dione); 7-Keto-DHEA; 19-Norandrosterone; 19-Noretiocholanolone; Androst-4-ene-3α,17α-diol; Androst-4-ene-3α,17β-diol; Androst-4-ene-3β,17α-diol; Androst-5-ene-3α,17α-diol; Androst-5-ene-3α,17β-diol; Androst-5-ene-3β,17α-diol; Androsterone; Epi-dihydrotestosterone; Epitestosterone; Etiocholanolone. 2. OTHER ANABOLIC AGENTS Including, but not limited to: • Clenbuterol; • Selective androgen receptor modulators (SARMs, e.g. andarine and ostarine); • Tibolone; • Zeranol; • Zilpaterol. For purposes of this section: * “exogenous” refers to a substance which is not ordinarily produced by the body naturally. ** “endogenous” refers to a substance which is ordinarily produced by the body naturally. PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES, AND MIMETICS The following substances, and other substances with similar chemical structure or similar biological effect(s), are prohibited: 1. Erythropoietin-Receptor agonists: 1.1 Erythropoiesis-Stimulating Agents (ESAs) including e.g. Darbepoietin (dEPO); Erythropoietins (EPO); EPO-Fc; EPO-mimetic peptides (EMP), e.g. CNTO 530 and peginesatide; GATA inhibitors, e.g. K-11706; Methoxy polyethylene glycol-epoetin beta (CERA); Transforming Growth Factor-β (TGF-β) inhibitors, e.g. sotatercept, luspatercept; 1.2 Non-erythropoietic EPO-Receptor agonists, e.g. ARA-290; Asialo EPO; Carbamylated EPO. 2. Hypoxia-inducible factor (HIF) stabilizers, e.g. cobalt, molidustat and roxadustat (FG-4592); and HIF activators, e.g. argon and xenon. S2 4 3. Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) and their releasing factors, e.g. buserelin, gonadorelin and leuprorelin, in males. 4. Corticotrophins and their releasing factors, e.g. corticorelin. 5. Growth Hormone (GH) and its releasing factors including: • Growth Hormone Releasing Hormone (GHRH) and its analogues, e.g. CJC-1295, sermorelin and tesamorelin; • Growth Hormone Secretagogues (GHS), e.g. ghrelin and ghrelin mimetics, e.g. anamorelin and ipamorelin; • GH-Releasing Peptides (GHRPs), e.g. alexamorelin, GHRP-6, hexarelin, and pralmorelin (GHRP-2). Additional prohibited growth factors: Fibroblast Growth Factors (FGFs); Hepatocyte Growth Factor (HGF); Insulin-like Growth Factor-1 (IGF-1) and its analogues; Mechano Growth Factors (MGFs); Platelet-Derived Growth Factor (PDGF); Vascular-Endothelial Growth Factor (VEGF) and any other growth factor affecting muscle, tendon or ligament protein synthesis/degradation, vascularisation, energy utilization, regenerative capacity, or fibre type switching. BETA-2 AGONISTS All selective and non-selective beta-2 agonists, including all optical isomers, are prohibited. Including, but not limited to: Fenoterol; Formoterol; Higenamine; Indacaterol; Olodaterol; Procaterol; Reproterol; Salbutamol; Salmeterol; Terbutaline; Vilanterol. S3 Except: • Inhaled salbutamol: maximum 1600 micrograms over 24 hours, not to exceed 800 micrograms every 12 hours; • Inhaled formoterol: maximum delivered dose of 54 micrograms over 24 hours; • Inhaled salmeterol: maximum 200 micrograms over 24 hours. The presence in urine of salbutamol in excess of 1000 ng/mL or formoterol in excess of 40 ng/mL is presumed not to be an intended therapeutic use of the substance and will be considered as an Adverse Analytical Finding (AAF) unless the Athlete proves, through a controlled pharmacokinetic study, that the abnormal result was the consequence of the use of the therapeutic dose (by inhalation) up to the maximum dose indicated above. HORMONE AND METABOLIC MODULATORS The following hormone and metabolic modulators are prohibited: 1. Aromatase inhibitors including, but not limited to: 4-Androstene-3,6,17 trione (6-oxo); Aminoglutethimide; Anastrozole; Androsta-1,4,6-triene-3,17-dione (androstatrienedione); Androsta-3,5-diene-7,17-dione (arimistane); Exemestane; Formestane; Letrozole; Testolactone. 2. Selective estrogen receptor modulators (SERMs) including, but not limited to: Raloxifene; Tamoxifen; Toremifene. 3. Other anti-estrogenic substances including, but not limited to: Clomiphene; Cyclofenil; Fulvestrant. S4 5 4. Agents modifying myostatin function(s) including, but not limited, to: myostatin inhibitors. 5. Metabolic modulators: 5.1 Activators of the AMP-activated protein kinase (AMPK), e.g. AICAR; and Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists, e.g. GW 1516; 5.2 Insulins and insulin-mimetics; 5.3 Meldonium; 5.4 Trimetazidine. DIURETICS AND MASKING AGENTS The following diuretics and masking agents are prohibited, as are other substances with a similar chemical structure or similar biological effect(s). Including, but not limited to: • Desmopressin; probenecid; plasma expanders, e.g. glycerol and intravenous administration of albumin, dextran, hydroxyethyl starch and mannitol; • Acetazolamide; amiloride; bumetanide; canrenone; chlortalidone; etacrynic acid; furosemide; indapamide; metolazone; spironolactone; thiazides, e.g. bendroflu- methiazide, chlorothiazide and hydrochlorothiazide; triamterene and vaptans, e.g. tolvaptan. Except: • Drospirenone; pamabrom; and ophthalmic use of carbonic anhydrase inhibitors (e.g. dorzolamide, brinzolamide); • Local administration of felypressin in dental anaesthesia. The detection in an Athlete’s Sample at all times or In-Competition, as applicable, of any quantity of the following substances subject to threshold limits: formoterol, salbutamol, cathine, ephedrine, methylephedrine and pseudoephedrine, in conjunction with a diuretic or masking agent, will be considered as an Adverse Analytical Finding (AAF) unless the Athlete has an approved Therapeutic Use Exemption (TUE) for that substance in addition to the one granted for the diuretic or masking agent. S5 PROHIBITED METHODS MANIPULATION OF BLOOD AND BLOOD COMPONENTS The following are prohibited: 1. The Administration or reintroduction of any quantity of autologous, allogenic (homologous) or heterologous blood, or red blood cell products of any origin into the circulatory system. 2. Artificially enhancing the uptake, transport or delivery of oxygen. Including, but not limited to: Perfluorochemicals; efaproxiral (RSR13) and modified haemoglobin products, e.g. haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen by inhalation. 3. Any form of intravascular manipulation of the blood or blood components by physical or chemical means. CHEMICAL AND PHYSICAL MANIPULATION The following are prohibited: 1. Tampering, or Attempting to Tamper, to alter the integrity and validity of Samples collected during Doping Control. Including, but not limited to: Urine substitution and/or adulteration, e.g. proteases. 2. Intravenous infusions and/or injections of more than 50 mL per 6 hour period except for those legitimately received in the course of hospital admissions, surgical procedures or clinical investigations. GENE DOPING The following, with the potential to enhance sport performance, are prohibited: 1. The transfer of polymers of nucleic acids or nucleic acid analogues. 2. The use of normal or genetically modified cells. M1 M2 M3 6 IN ADDITION TO THE CATEGORIES S0 TO S5 AND M1 TO M3 DEFINED ABOVE, THE FOLLOWING CATEGORIES ARE PROHIBITED IN-COMPETITION: SUBSTANCES & METHODS PROHIBITED IN-COMPETITION PROHIBITED SUBSTANCES STIMULANTS All stimulants, including all optical isomers, e.g. d- and l- where relevant, are prohibited. Stimulants include: a: Non-Specified Stimulants: Adrafinil; Amfepramone; Amfetamine; Amfetaminil; Amiphenazole; Benfluorex; Benzylpiperazine; Bromantan; Clobenzorex; Cocaine; Cropropamide; Crotetamide; Fencamine; Fenetylline; Fenfluramine; Fenproporex; Fonturacetam [4-phenylpiracetam (carphedon)]; Furfenorex; Lisdexamfetamine; Mefenorex; Mephentermine; Mesocarb; Metamfetamine(d-); p-methylamphetamine; Modafinil; Norfenfluramine; Phendimetrazine; Phentermine; Prenylamine; Prolintane. A stimulant not expressly listed in this section is a Specified Substance. S6 b: Specified Stimulants. Including, but not limited to: 4-Methylhexan-2-amine (methylhexaneamine); Benzfetamine; Cathine**; Cathinone and its analogues, e.g. mephedrone, methedrone, and α- pyrrolidinovalerophenone; Dimethylamphetamine; Ephedrine***; Epinephrine**** (adrenaline); Etamivan; Etilamfetamine; Etilefrine; Famprofazone; Fenbutrazate; Fencamfamin; Heptaminol; Hydroxyamfetamine (parahydroxyamphetamine); Isometheptene; Levmetamfetamine; Meclofenoxate; Methylenedioxymethamphetamine; Methylephedrine***; Methylphenidate; Nikethamide; Norfenefrine; Octopamine; Oxilofrine (methylsynephrine); Pemoline; Pentetrazol; Phenethylamine and its derivatives; Phenmetrazine; Phenpromethamine; Propylhexedrine; Pseudoephedrine*****; 7 Selegiline; Sibutramine; Strychnine; Tenamfetamine (methylenedioxyamphetamine); Tuaminoheptane; and other substances with a similar chemical structure or similar biological effect(s). Except: • Clonidine; • Imidazole derivatives for topical/ophthalmic use and those stimulants included in the 2017 Monitoring Program*. * Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradrol, and synephrine: These substances are included in the 2017 Monitoring Program, and are not considered Prohibited Substances. ** Cathine: Prohibited when its concentration in urine is greater than 5 micrograms per milliliter. *** Ephedrine and methylephedrine: Prohibited when the concentration of either in urine is greater than 10 micrograms per milliliter. **** Epinephrine (adrenaline): Not prohibited in local administration, e.g. nasal, ophthalmologic, or co-administration with local anaesthetic agents. ***** Pseudoephedrine: Prohibited when its concentration in urine is greater than 150 micrograms per milliliter. NARCOTICS Prohibited: Buprenorphine; Dextromoramide; Diamorphine (heroin); Fentanyl and its derivatives; Hydromorphone; Methadone; Morphine; Nicomorphine; Oxycodone; Oxymorphone; Pentazocine; Pethidine. CANNABINOIDS Prohibited: • Natural, e.g. cannabis, hashish and marijuana, or synthetic Δ9-tetrahydrocannabinol (THC). • Cannabimimetics, e.g. “Spice”, JWH-018, JWH-073, HU-210. GLUCOCORTICOIDS All glucocorticoids are prohibited when administered by oral, intravenous, intramuscular, or rectal routes. S7 S8 S9 8 SUBSTANCES PROHIBITED IN PARTICULAR SPORTS ALCOHOL Alcohol (ethanol) is prohibited In-Competition only, in the following sports. Detection will be conducted by analysis of breath and/or blood. The doping violation threshold is equivalent to a blood alcohol concentration of 0.10 g/L. • Air Sports (FAI) • Automobile (FIA) • Archery (WA) • Powerboating (UIM) P1 BETA-BLOCKERS Beta-blockers are prohibited In-Competition only, in the following sports, and also prohibited Out-of-Competition where indicated. • Archery (WA)* • Automobile (FIA) • Billiards (all disciplines) (WCBS) • Darts (WDF) • Golf (IGF) • Shooting (ISSF, IPC)* • Skiing/Snowboarding (FIS) in ski jumping, freestyle aerials/halfpipe and snowboard halfpipe/big air • Underwater sports (CMAS) in constant-weight apnoea with or without fins, dynamic apnoea with and without fins, free immersion apnoea, Jump Blue apnoea, spearfishing, static apnoea, target shooting, and variable weight apnoea. *Also prohibited Out-of-Competition Including, but not limited to: Acebutolol; Labetalol; Alprenolol; Levobunolol; Atenolol; Metipranolol; Betaxolol; Metoprolol; Bisoprolol; Nadolol; Bunolol; Oxprenolol; Carteolol; Pindolol; Carvedilol; Propranolol; Celiprolol; Sotalol; Esmolol; Timolol. P2 www.wada-ama.org

1 Prohibited Substances ANABOLIC AGENTS • Dihydrotestosterone was renamed to its International Non-proprietary Name (INN) (androstanolone). 1-androsterone (3α-hydroxy-5α-androst-1-ene-17-one) was added in S1.a as an example of exogenous anabolic steroid. • LGD-4033 and RAD140 were added as further examples of SARMs. PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES AND MIMETICS • For clarity and accuracy Section S2 was reorganized. • ARA290 was removed as an example in this section because current literature suggests it does not meet inclusion criteria. • Deslorelin, goserelin, nafarelin and triptorelin were added as examples of 2.1. • Growth Hormone fragments were included in 2.3 with AOD-9604 and hGH 176-191 added as examples; CJC-1293 was added as example of GHRH and tabimorelin as a further example of GH secretagogue. GHRP-1, -3, -4, and -5 were added as examples of GHRP. • Thymosin- β4 and its derivatives, e. g. TB-500, were added as example of prohibited growth factors. • Cobalt: It is re-iterated that vitamin B12, which contains cobalt, is not prohibited. S1 S2 BETA-2-AGONISTS • Dosing parameters of salbutamol were revised to make it clear that divided doses of salbutamol may not exceed 800 micrograms over any 12 hours (see figure). Inhaled salbutamol – max. 1600 mcg over 24 hours But not to exceed 800 mcg over any 12 hours 0 12 24 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg • Tulobuterol was added as an example. • The statement on the urinary thresholds was improved. HORMONE AND METABOLIC MODULATORS • Clomifene is now stated by its INN. • In the absence of an INN, the IUPAC name of GW1516, 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl) thiazol-5-yl)methylthio)phenoxy) acetic acid as well as an alternative name (GW501516) were included. • SR9009, a Rev-Erb-α agonist, was added as an example of Activators of the AMP-activated protein kinase (AMPK). S3 Any 12 hour period: max. 800 mcg S4 SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES 2018 PROHIBITED LIST Substances and methods prohibited at all times (In- and Out-of-Competition) 2 DIURETICS AND MASKING AGENTS • In consideration of the information published in scientific articles since 2012 that particularly addresses the ability of glycerol to influence the athlete‘s plasma volume and parameters of the Athlete Biological Passport (ABP), the magnitude of glycerol-derived effects is regarded as minimal. Therefore, glycerol has been removed from the Prohibited List. Prohibited Methods CHEMICAL AND PHYSICAL MANIPULATION • M2.2: the permitted volume and timing of intravenous infusions were changed from infusions of no more than 50 mL per 6-hour period to no more than a total of 100 mL per 12-hour period in order to allow greater flexibility for the safe administration of non-prohibited therapeutic substances, for example, iron. • To reflect medical practice, “hospital admissions” has been changed to “hospital treatments” and “clinical investigations” has been clarified as “clinical diagnostic investigations”. GENE DOPING • The definition has been revised to include current and emerging gene manipulating technologies. Substances and Methods Prohibited In-Competition STIMULANTS • 1,3-Dimethylbutylamine was added as an example. This substance can be found in some dietary supplements. S5 M2 M3 S6 CANNABINOIDS • The category Cannabimimetics, e.g. “Spice, JWH-018, JWH-073, HU210” was changed to “synthetic cannabinoids, e.g. Δ9-tetrahydrocannabinol (THC) and other cannabimimetics”. The synthetic cannabinoids are one of the main classes of novel psychoactive substances that have constantly emerging new drugs and changing availability. The previous list of examples continues to be prohibited, but are currently used less commonly. “Other cannabimimetics” replaced these examples. • Cannabidiol is no longer prohibited. Synthetic cannabidiol is not a cannabimimetic; however, cannabidiol extracted from cannabis plants may also contain varying concentrations of THC, which remains a prohibited substance. GLUCOCORTICOIDS • Examples of commonly used glucocorticoids were added for greater clarity. S8 S9 3 Substances Prohibited in Particular Sports ALCOHOL • After careful consideration and extensive consultation, Alcohol was excluded from the Prohibited List. The intent of this change is not to compromise the integrity or safety of any sport where alcohol use is a concern, but rather to endorse a different means of enforcing bans on alcohol use in these sports. The four International Federations (IF) affected by this change have been alerted sufficiently in advance in order to amend their rules and to put in place protocols to test for alcohol use and appropriately sanction athletes who do not abide by the rules of their sport. Control of the process will allow IF more flexibility in applying rules or thresholds as they see fit. The National Anti-Doping Organizations are no longer obliged to conduct tests but may assist IF and National Federations where appropriate. BETA BLOCKERS • For logical consistency, the category known as P2. Beta Blockers was renamed P1. Beta Blockers. MONITORING PROGRAM The following were added to evaluate misuse in sport: • 2-ethylsulfanyl-1H-benzimidazole (bemitil) in- and out-of-competition • Hydrocodone in-competition. Mitragynine and telmisartan were removed from the Monitoring Program because the required information on prevalence was obtained. P1 P2

1 Prohibited Substances ANABOLIC AGENTS • Dihydrotestosterone was renamed to its International Non-proprietary Name (INN) (androstanolone). 1-androsterone (3α-hydroxy-5α-androst-1-ene-17-one) was added in S1.a as an example of exogenous anabolic steroid. • LGD-4033 and RAD140 were added as further examples of SARMs. PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES AND MIMETICS • For clarity and accuracy Section S2 was reorganized. • ARA290 was removed as an example in this section because current literature suggests it does not meet inclusion criteria. • Deslorelin, goserelin, nafarelin and triptorelin were added as examples of 2.1. • Growth Hormone fragments were included in 2.3 with AOD-9604 and hGH 176-191 added as examples; CJC-1293 was added as example of GHRH and tabimorelin as a further example of GH secretagogue. GHRP-1, -3, -4, and -5 were added as examples of GHRP. • Thymosin- β4 and its derivatives, e. g. TB-500, were added as example of prohibited growth factors. • Cobalt: It is re-iterated that vitamin B12, which contains cobalt, is not prohibited. S1 S2 BETA-2-AGONISTS • Dosing parameters of salbutamol were revised to make it clear that divided doses of salbutamol may not exceed 800 micrograms over any 12 hours (see figure). Inhaled salbutamol – max. 1600 mcg over 24 hours But not to exceed 800 mcg over any 12 hours 0 12 24 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg • Tulobuterol was added as an example. • The statement on the urinary thresholds was improved. HORMONE AND METABOLIC MODULATORS • Clomifene is now stated by its INN. • In the absence of an INN, the IUPAC name of GW1516, 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl) thiazol-5-yl)methylthio)phenoxy) acetic acid as well as an alternative name (GW501516) were included. • SR9009, a Rev-Erb-α agonist, was added as an example of Activators of the AMP-activated protein kinase (AMPK). S3 Any 12 hour period: max. 800 mcg S4 SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES 2018 PROHIBITED LIST Substances and methods prohibited at all times (In- and Out-of-Competition) 2 DIURETICS AND MASKING AGENTS • In consideration of the information published in scientific articles since 2012 that particularly addresses the ability of glycerol to influence the athlete‘s plasma volume and parameters of the Athlete Biological Passport (ABP), the magnitude of glycerol-derived effects is regarded as minimal. Therefore, glycerol has been removed from the Prohibited List. Prohibited Methods CHEMICAL AND PHYSICAL MANIPULATION • M2.2: the permitted volume and timing of intravenous infusions were changed from infusions of no more than 50 mL per 6-hour period to no more than a total of 100 mL per 12-hour period in order to allow greater flexibility for the safe administration of non-prohibited therapeutic substances, for example, iron. • To reflect medical practice, “hospital admissions” has been changed to “hospital treatments” and “clinical investigations” has been clarified as “clinical diagnostic investigations”. GENE DOPING • The definition has been revised to include current and emerging gene manipulating technologies. Substances and Methods Prohibited In-Competition STIMULANTS • 1,3-Dimethylbutylamine was added as an example. This substance can be found in some dietary supplements. S5 M2 M3 S6 CANNABINOIDS • The category Cannabimimetics, e.g. “Spice, JWH-018, JWH-073, HU210” was changed to “synthetic cannabinoids, e.g. Δ9-tetrahydrocannabinol (THC) and other cannabimimetics”. The synthetic cannabinoids are one of the main classes of novel psychoactive substances that have constantly emerging new drugs and changing availability. The previous list of examples continues to be prohibited, but are currently used less commonly. “Other cannabimimetics” replaced these examples. • Cannabidiol is no longer prohibited. Synthetic cannabidiol is not a cannabimimetic; however, cannabidiol extracted from cannabis plants may also contain varying concentrations of THC, which remains a prohibited substance. GLUCOCORTICOIDS • Examples of commonly used glucocorticoids were added for greater clarity. S8 S9 3 Substances Prohibited in Particular Sports ALCOHOL • After careful consideration and extensive consultation, Alcohol was excluded from the Prohibited List. The intent of this change is not to compromise the integrity or safety of any sport where alcohol use is a concern, but rather to endorse a different means of enforcing bans on alcohol use in these sports. The four International Federations (IF) affected by this change have been alerted sufficiently in advance in order to amend their rules and to put in place protocols to test for alcohol use and appropriately sanction athletes who do not abide by the rules of their sport. Control of the process will allow IF more flexibility in applying rules or thresholds as they see fit. The National Anti-Doping Organizations are no longer obliged to conduct tests but may assist IF and National Federations where appropriate. BETA BLOCKERS • For logical consistency, the category known as P2. Beta Blockers was renamed P1. Beta Blockers. MONITORING PROGRAM The following were added to evaluate misuse in sport: • 2-ethylsulfanyl-1H-benzimidazole (bemitil) in- and out-of-competition • Hydrocodone in-competition. Mitragynine and telmisartan were removed from the Monitoring Program because the required information on prevalence was obtained. P1 P2

THE WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2018 The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. This List shall come into effect on 1 January 2018 2 IN ACCORDANCE WITH ARTICLE 4.2.2 OF THE WORLD ANTI-DOPING CODE, ALL PROHIBITED SUBSTANCES SHALL BE CONSIDERED AS “SPECIFIED SUBSTANCES” EXCEPT SUBSTANCES IN CLASSES S1, S2, S4.4, S4.5, S6.A, AND PROHIBITED METHODS M1, M2 AND M3. PROHIBITED SUBSTANCES SUBSTANCES & METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) NON-APPROVED SUBSTANCES Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times. ANABOLIC AGENTS Anabolic agents are prohibited. 1. ANABOLIC ANDROGENIC STEROIDS (AAS) a. Exogenous* AAS, including: 1-Androstenediol (5α-androst-1-ene-3β,17β-diol); 1-Androstenedione (5α-androst-1-ene-3,17-dione); 1-Androsterone (3α-hydroxy-5α-androst-1-ene-17-one); 1-Testosterone (17β-hydroxy-5α-androst-1-en-3-one); 4-Hydroxytestosterone (4,17β-dihydroxyandrost-4-en-3- one); Bolandiol (estr-4-ene-3β,17β-diol); Bolasterone; Calusterone; Clostebol; Danazol ([1,2]oxazolo[4',5':2,3]pregna-4-en-20-yn-17α-ol); Dehydrochlormethyltestosterone (4-chloro-17β-hydroxy- 17α-methylandrosta-1,4-dien-3-one); Desoxymethyltestosterone (17α-methyl-5α-androst- 2-en-17β-ol); Drostanolone; Ethylestrenol (19-norpregna-4-en-17α-ol); Fluoxymesterone; Formebolone; Furazabol (17α-methyl [1,2,5]oxadiazolo[3',4':2,3]-5α- androstan-17β-ol); Gestrinone; S0 S1 Mestanolone; Mesterolone; Metandienone (17β-hydroxy-17α-methylandrosta-1,4-dien- 3-one); Metenolone; Methandriol; Methasterone (17β-hydroxy-2α,17α-dimethyl-5α- androstan-3-one); Methyldienolone (17β-hydroxy-17α-methylestra-4,9-dien- 3-one); Methyl-1-testosterone (17β-hydroxy-17α-methyl-5α- androst-1-en-3-one); Methylnortestosterone (17β-hydroxy-17α-methylestr-4-en- 3-one); Methyltestosterone; Metribolone (methyltrienolone, 17β-hydroxy-17α- methylestra-4,9,11-trien-3-one); Mibolerone; Norboletone; Norclostebol; Norethandrolone; Oxabolone; Oxandrolone; Oxymesterone; Oxymetholone; Prostanozol (17β-[(tetrahydropyran-2-yl)oxy]-1'H- pyrazolo[3,4:2,3]-5α-androstane); Quinbolone; Stanozolol; Stenbolone; Tetrahydrogestrinone (17-hydroxy-18a-homo-19-nor-17α- pregna-4,9,11-trien-3-one); Trenbolone (17β-hydroxyestr-4,9,11-trien-3-one); and other substances with a similar chemical structure or similar biological effect(s). 3 b. Endogenous** AAS when administered exogenously: 19-Norandrostenediol (estr-4-ene-3,17-diol); 19-Norandrostenedione (estr-4-ene-3,17-dione); Androstanolone (5α-dihydrotestosterone, 17β-hydroxy-5α- androstan-3-one); Androstenediol (androst-5-ene-3β,17β-diol); Androstenedione (androst-4-ene-3,17-dione); Boldenone; Boldione (androsta-1,4-diene-3,17-dione); Nandrolone (19-nortestosterone); Prasterone (dehydroepiandrosterone, DHEA, 3β-hydroxyandrost-5-en-17-one); Testosterone; and their metabolites and isomers, including but not limited to: 3β-Hydroxy-5α-androstan-17-one; 5α-Androst-2-ene-17-one; 5α-Androstane-3α,17α-diol; 5α-Androstane-3α,17β-diol; 5α-Androstane-3β,17α-diol; 5α-Androstane-3β,17β-diol; 5β-Androstane-3α,17β-diol; 7α-Hydroxy-DHEA; 7β-Hydroxy-DHEA; 4-Androstenediol (androst-4-ene-3β, 17β-diol); 5-Androstenedione (androst-5-ene-3,17-dione); 7-Keto-DHEA; 19-Norandrosterone; 19-Noretiocholanolone; Androst-4-ene-3α,17α-diol; Androst-4-ene-3α,17β-diol; Androst-4-ene-3β,17α-diol; Androst-5-ene-3α,17α-diol; Androst-5-ene-3α,17β-diol; Androst-5-ene-3β,17α-diol; Androsterone; Epi-dihydrotestosterone; Epitestosterone; Etiocholanolone. 2. OTHER ANABOLIC AGENTS Including, but not limited to: Clenbuterol, selective androgen receptor modulators (SARMs, e.g. andarine, LGD-4033, ostarine and RAD140), tibolone, zeranol and zilpaterol. For purposes of this section: * “exogenous” refers to a substance which is not ordinarily produced by the body naturally. ** “endogenous” refers to a substance which is ordinarily produced by the body naturally. PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES, AND MIMETICS The following substances, and other substances with similar chemical structure or similar biological effect(s), are prohibited: 1. Erythropoietins (EPO) and agents affecting erythropoiesis, including, but not limited to: 1.1 Erythropoietin-Receptor Agonists, e.g. Darbepoetins (dEPO); Erythropoietins (EPO); EPO based constructs [EPO-Fc, methoxy polyethylene glycol-epoetin beta (CERA)]; EPO-mimetic agents and their constructs (e.g. CNTO-530, peginesatide). 1.2 Hypoxia-inducible factor (HIF) activating agents, e.g. Argon; Cobalt; Molidustat; Roxadustat (FG-4592); Xenon. 1.3 GATA inhibitors, e.g. K-11706. 1.4 TGF-beta (TGF-β) inhibitors, e.g. Luspatercept; Sotatercept. S2 4 1.5 Innate repair receptor agonists, e.g. Asialo EPO; Carbamylated EPO (CEPO). 2. Peptide Hormones and Hormone Modulators, 2.1 Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) and their releasing factors, e.g. Buserelin, deslorelin, gonadorelin, goserelin, leuprorelin, nafarelin and triptorelin, in males; 2.2 Corticotrophins and their releasing factors, e.g. Corticorelin; 2.3 Growth Hormone (GH), its fragments and releasing factors, including, but not limited to: Growth Hormone fragments, e.g. AOD-9604 and hGH 176-191; Growth Hormone Releasing Hormone (GHRH) and its analogues, e.g. CJC-1293, CJC-1295, sermorelin and tesamorelin; Growth Hormone Secretagogues (GHS), e.g. ghrelin and ghrelin mimetics, e.g. anamorelin, ipamorelin and tabimorelin; GH-Releasing Peptides (GHRPs), e.g. alexamorelin, GHRP-1, GHRP-2 (pralmorelin), GHRP-3, GHRP-4, GHRP-5, GHRP-6, and hexarelin. 3. Growth Factors and Growth Factor Modulators, including, but not limited to: Fibroblast Growth Factors (FGFs); Hepatocyte Growth Factor (HGF); Insulin-like Growth Factor-1 (IGF-1) and its analogues; Mechano Growth Factors (MGFs); Platelet-Derived Growth Factor (PDGF); Thymosin-β4 and its derivatives e.g. TB-500; Vascular-Endothelial Growth Factor (VEGF). Additional growth factors or growth factor modulators affecting muscle, tendon or ligament protein synthesis/ degradation, vascularisation, energy utilization, regenerative capacity or fibre type switching. BETA-2 AGONISTS All selective and non-selective beta-2 agonists, including all optical isomers, are prohibited. Including, but not limited to: Fenoterol; Formoterol; Higenamine; Indacaterol; Olodaterol; Procaterol; Reproterol; Salbutamol; Salmeterol; Terbutaline; Tulobuterol; Vilanterol. Except: • Inhaled salbutamol: maximum 1600 micrograms over 24 hours in divided doses not to exceed 800 micrograms over 12 hours starting from any dose; • Inhaled formoterol: maximum delivered dose of 54 micrograms over 24 hours; • Inhaled salmeterol: maximum 200 micrograms over 24 hours. The presence in urine of salbutamol in excess of 1000 ng/mL or formoterol in excess of 40 ng/mL is not consistent with therapeutic use of the substance and will be considered as an Adverse Analytical Finding (AAF) unless the Athlete proves, through a controlled pharmacokinetic study, that the abnormal result was the consequence of a therapeutic dose (by inhalation) up to the maximum dose indicated above. HORMONE AND METABOLIC MODULATORS The following hormone and metabolic modulators are prohibited: 1. Aromatase inhibitors including, but not limited to: 4-Androstene-3,6,17 trione (6-oxo); Aminoglutethimide; Anastrozole; Androsta-1,4,6-triene-3,17-dione (androstatrienedione); S3 S4 5 Androsta-3,5-diene-7,17-dione (arimistane); Exemestane; Formestane; Letrozole; Testolactone. 2. Selective estrogen receptor modulators (SERMs) including, but not limited to: Raloxifene; Tamoxifen; Toremifene. 3. Other anti-estrogenic substances including, but not limited to: Clomifene; Cyclofenil; Fulvestrant. 4. Agents modifying myostatin function(s) including, but not limited, to: myostatin inhibitors. 5. Metabolic modulators: 5.1 Activators of the AMP-activated protein kinase (AMPK), e.g. AICAR, SR9009; and Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists, e.g. 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl) phenyl)thiazol-5-yl)methylthio)phenoxy) acetic acid (GW1516, GW501516); 5.2 Insulins and insulin-mimetics; 5.3 Meldonium; 5.4 Trimetazidine. DIURETICS AND MASKING AGENTS The following diuretics and masking agents are prohibited, as are other substances with a similar chemical structure or similar biological effect(s). Including, but not limited to: • Desmopressin; probenecid; plasma expanders, e.g. intravenous administration of albumin, dextran, hydroxyethyl starch and mannitol. • Acetazolamide; amiloride; bumetanide; canrenone; chlortalidone; etacrynic acid; furosemide; indapamide; metolazone; spironolactone; thiazides, e.g. bendroflu- methiazide, chlorothiazide and hydrochlorothiazide; triamterene and vaptans, e.g. tolvaptan. S5 Except: • Drospirenone; pamabrom; and ophthalmic use of carbonic anhydrase inhibitors (e.g. dorzolamide, brinzolamide); • Local administration of felypressin in dental anaesthesia. The detection in an Athlete’s Sample at all times or In-Competition, as applicable, of any quantity of the following substances subject to threshold limits: formoterol, salbutamol, cathine, ephedrine, methylephedrine and pseudoephedrine, in conjunction with a diuretic or masking agent, will be considered as an Adverse Analytical Finding (AAF) unless the Athlete has an approved Therapeutic Use Exemption (TUE) for that substance in addition to the one granted for the diuretic or masking agent. 6 PROHIBITED METHODS MANIPULATION OF BLOOD AND BLOOD COMPONENTS The following are prohibited: 1. The Administration or reintroduction of any quantity of autologous, allogenic (homologous) or heterologous blood, or red blood cell products of any origin into the circulatory system. 2. Artificially enhancing the uptake, transport or delivery of oxygen. Including, but not limited to: Perfluorochemicals; efaproxiral (RSR13) and modified haemoglobin products, e.g. haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen by inhalation. 3. Any form of intravascular manipulation of the blood or blood components by physical or chemical means. CHEMICAL AND PHYSICAL MANIPULATION The following are prohibited: 1. Tampering, or Attempting to Tamper, to alter the integrity and validity of Samples collected during Doping Control. Including, but not limited to: Urine substitution and/or adulteration, e.g. proteases. 2. Intravenous infusions and/or injections of more than a total of 100 mL per 12 hour period except for those legitimately received in the course of hospital treatments, surgical procedures or clinical diagnostic investigations. M1 M2 GENE DOPING The following, with the potential to enhance sport performance, are prohibited: 1. The use of polymers of nucleic acids or nucleic acid analogues. 2. The use of gene editing agents designed to alter genome sequences and/or the transcriptional or epigenetic regulation of gene expression. 3. The use of normal or genetically modified cells. M3 7 IN ADDITION TO THE CATEGORIES S0 TO S5 AND M1 TO M3 DEFINED ABOVE, THE FOLLOWING CATEGORIES ARE PROHIBITED IN-COMPETITION: SUBSTANCES & METHODS PROHIBITED IN-COMPETITION PROHIBITED SUBSTANCES STIMULANTS All stimulants, including all optical isomers, e.g. d- and l- where relevant, are prohibited. Stimulants include: a: Non-Specified Stimulants: Adrafinil; Amfepramone; Amfetamine; Amfetaminil; Amiphenazole; Benfluorex; Benzylpiperazine; Bromantan; Clobenzorex; Cocaine; Cropropamide; Crotetamide; Fencamine; Fenetylline; Fenfluramine; Fenproporex; Fonturacetam [4-phenylpiracetam (carphedon)]; Furfenorex; Lisdexamfetamine; Mefenorex; Mephentermine; Mesocarb; Metamfetamine(d-); p-methylamphetamine; Modafinil; Norfenfluramine; Phendimetrazine; Phentermine; Prenylamine; Prolintane. A stimulant not expressly listed in this section is a Specified Substance. S6 b: Specified Stimulants. Including, but not limited to: 1,3-Dimethylbutylamine; 4-Methylhexan-2-amine (methylhexaneamine); Benzfetamine; Cathine**; Cathinone and its analogues, e.g. mephedrone, methedrone, and α - pyrrolidinovalerophenone; Dimethylamphetamine; Ephedrine***; Epinephrine**** (adrenaline); Etamivan; Etilamfetamine; Etilefrine; Famprofazone; Fenbutrazate; Fencamfamin; Heptaminol; Hydroxyamfetamine (parahydroxyamphetamine); Isometheptene; Levmetamfetamine; Meclofenoxate; Methylenedioxymethamphetamine; Methylephedrine***; Methylphenidate; Nikethamide; Norfenefrine; Octopamine; Oxilofrine (methylsynephrine); Pemoline; Pentetrazol; Phenethylamine and its derivatives; Phenmetrazine; Phenpromethamine; Propylhexedrine; Pseudoephedrine*****; 8 Selegiline; Sibutramine; Strychnine; Tenamfetamine (methylenedioxyamphetamine); Tuaminoheptane; and other substances with a similar chemical structure or similar biological effect(s). Except: • Clonidine; • Imidazole derivatives for topical/ophthalmic use and those stimulants included in the 2018 Monitoring Program*. * Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradrol, and synephrine: These substances are included in the 2018 Monitoring Program, and are not considered Prohibited Substances. ** Cathine: Prohibited when its concentration in urine is greater than 5 micrograms per milliliter. *** Ephedrine and methylephedrine: Prohibited when the concentration of either in urine is greater than 10 micrograms per milliliter. **** Epinephrine (adrenaline): Not prohibited in local administration, e.g. nasal, ophthalmologic, or co-administration with local anaesthetic agents. ***** Pseudoephedrine: Prohibited when its concentration in urine is greater than 150 micrograms per milliliter. NARCOTICS The following narcotics are prohibited: Buprenorphine; Dextromoramide; Diamorphine (heroin); Fentanyl and its derivatives; Hydromorphone; Methadone; Morphine; Nicomorphine; Oxycodone; Oxymorphone; Pentazocine; Pethidine. CANNABINOIDS The following cannabinoids are prohibited: • Natural cannabinoids, e.g. cannabis, hashish and marijuana, • Synthetic cannabinoids e.g. Δ9-tetrahydrocannabinol (THC) and other cannabimimetics. Except: • Cannabidiol. GLUCOCORTICOIDS All glucocorticoids are prohibited when administered by oral, intravenous, intramuscular or rectal routes. Including but not limited to: Betamethasone; Budesonide; Cortisone; Deflazacort; Dexamethasone; Fluticasone; Hydrocortisone; Methylprednisolone; Prednisolone; Prednisone; Triamcinolone. S7 S8 S9 9 SUBSTANCES PROHIBITED IN PARTICULAR SPORTS BETA-BLOCKERS Beta-blockers are prohibited In-Competition only, in the following sports, and also prohibited Out-of-Competition where indicated. • Archery (WA)* • Automobile (FIA) • Billiards (all disciplines) (WCBS) • Darts (WDF) • Golf (IGF) • Shooting (ISSF, IPC)* • Skiing/Snowboarding (FIS) in ski jumping, freestyle aerials/halfpipe and snowboard halfpipe/big air • Underwater sports (CMAS) in constant-weight apnoea with or without fins, dynamic apnoea with and without fins, free immersion apnoea, Jump Blue apnoea, spearfishing, static apnoea, target shooting, and variable weight apnoea. *Also prohibited Out-of-Competition Including, but not limited to: Acebutolol; Labetalol; Alprenolol; Levobunolol; Atenolol; Metipranolol; Betaxolol; Metoprolol; Bisoprolol; Nadolol; Bunolol; Oxprenolol; Carteolol; Pindolol; Carvedilol; Propranolol; Celiprolol; Sotalol; Esmolol; Timolol. P1 www.wada-ama.org

THE WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2018 The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. This List shall come into effect on 1 January 2018 2 IN ACCORDANCE WITH ARTICLE 4.2.2 OF THE WORLD ANTI-DOPING CODE, ALL PROHIBITED SUBSTANCES SHALL BE CONSIDERED AS “SPECIFIED SUBSTANCES” EXCEPT SUBSTANCES IN CLASSES S1, S2, S4.4, S4.5, S6.A, AND PROHIBITED METHODS M1, M2 AND M3. PROHIBITED SUBSTANCES SUBSTANCES & METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) NON-APPROVED SUBSTANCES Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times. ANABOLIC AGENTS Anabolic agents are prohibited. 1. ANABOLIC ANDROGENIC STEROIDS (AAS) a. Exogenous* AAS, including: 1-Androstenediol (5α-androst-1-ene-3β,17β-diol); 1-Androstenedione (5α-androst-1-ene-3,17-dione); 1-Androsterone (3α-hydroxy-5α-androst-1-ene-17-one); 1-Testosterone (17β-hydroxy-5α-androst-1-en-3-one); 4-Hydroxytestosterone (4,17β-dihydroxyandrost-4-en-3- one); Bolandiol (estr-4-ene-3β,17β-diol); Bolasterone; Calusterone; Clostebol; Danazol ([1,2]oxazolo[4',5':2,3]pregna-4-en-20-yn-17α-ol); Dehydrochlormethyltestosterone (4-chloro-17β-hydroxy- 17α-methylandrosta-1,4-dien-3-one); Desoxymethyltestosterone (17α-methyl-5α-androst- 2-en-17β-ol); Drostanolone; Ethylestrenol (19-norpregna-4-en-17α-ol); Fluoxymesterone; Formebolone; Furazabol (17α-methyl [1,2,5]oxadiazolo[3',4':2,3]-5α- androstan-17β-ol); Gestrinone; S0 S1 Mestanolone; Mesterolone; Metandienone (17β-hydroxy-17α-methylandrosta-1,4-dien- 3-one); Metenolone; Methandriol; Methasterone (17β-hydroxy-2α,17α-dimethyl-5α- androstan-3-one); Methyldienolone (17β-hydroxy-17α-methylestra-4,9-dien- 3-one); Methyl-1-testosterone (17β-hydroxy-17α-methyl-5α- androst-1-en-3-one); Methylnortestosterone (17β-hydroxy-17α-methylestr-4-en- 3-one); Methyltestosterone; Metribolone (methyltrienolone, 17β-hydroxy-17α- methylestra-4,9,11-trien-3-one); Mibolerone; Norboletone; Norclostebol; Norethandrolone; Oxabolone; Oxandrolone; Oxymesterone; Oxymetholone; Prostanozol (17β-[(tetrahydropyran-2-yl)oxy]-1'H- pyrazolo[3,4:2,3]-5α-androstane); Quinbolone; Stanozolol; Stenbolone; Tetrahydrogestrinone (17-hydroxy-18a-homo-19-nor-17α- pregna-4,9,11-trien-3-one); Trenbolone (17β-hydroxyestr-4,9,11-trien-3-one); and other substances with a similar chemical structure or similar biological effect(s). 3 b. Endogenous** AAS when administered exogenously: 19-Norandrostenediol (estr-4-ene-3,17-diol); 19-Norandrostenedione (estr-4-ene-3,17-dione); Androstanolone (5α-dihydrotestosterone, 17β-hydroxy-5α- androstan-3-one); Androstenediol (androst-5-ene-3β,17β-diol); Androstenedione (androst-4-ene-3,17-dione); Boldenone; Boldione (androsta-1,4-diene-3,17-dione); Nandrolone (19-nortestosterone); Prasterone (dehydroepiandrosterone, DHEA, 3β-hydroxyandrost-5-en-17-one); Testosterone; and their metabolites and isomers, including but not limited to: 3β-Hydroxy-5α-androstan-17-one; 5α-Androst-2-ene-17-one; 5α-Androstane-3α,17α-diol; 5α-Androstane-3α,17β-diol; 5α-Androstane-3β,17α-diol; 5α-Androstane-3β,17β-diol; 5β-Androstane-3α,17β-diol; 7α-Hydroxy-DHEA; 7β-Hydroxy-DHEA; 4-Androstenediol (androst-4-ene-3β, 17β-diol); 5-Androstenedione (androst-5-ene-3,17-dione); 7-Keto-DHEA; 19-Norandrosterone; 19-Noretiocholanolone; Androst-4-ene-3α,17α-diol; Androst-4-ene-3α,17β-diol; Androst-4-ene-3β,17α-diol; Androst-5-ene-3α,17α-diol; Androst-5-ene-3α,17β-diol; Androst-5-ene-3β,17α-diol; Androsterone; Epi-dihydrotestosterone; Epitestosterone; Etiocholanolone. 2. OTHER ANABOLIC AGENTS Including, but not limited to: Clenbuterol, selective androgen receptor modulators (SARMs, e.g. andarine, LGD-4033, ostarine and RAD140), tibolone, zeranol and zilpaterol. For purposes of this section: * “exogenous” refers to a substance which is not ordinarily produced by the body naturally. ** “endogenous” refers to a substance which is ordinarily produced by the body naturally. PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES, AND MIMETICS The following substances, and other substances with similar chemical structure or similar biological effect(s), are prohibited: 1. Erythropoietins (EPO) and agents affecting erythropoiesis, including, but not limited to: 1.1 Erythropoietin-Receptor Agonists, e.g. Darbepoetins (dEPO); Erythropoietins (EPO); EPO based constructs [EPO-Fc, methoxy polyethylene glycol-epoetin beta (CERA)]; EPO-mimetic agents and their constructs (e.g. CNTO-530, peginesatide). 1.2 Hypoxia-inducible factor (HIF) activating agents, e.g. Argon; Cobalt; Molidustat; Roxadustat (FG-4592); Xenon. 1.3 GATA inhibitors, e.g. K-11706. 1.4 TGF-beta (TGF-β) inhibitors, e.g. Luspatercept; Sotatercept. S2 4 1.5 Innate repair receptor agonists, e.g. Asialo EPO; Carbamylated EPO (CEPO). 2. Peptide Hormones and Hormone Modulators, 2.1 Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) and their releasing factors, e.g. Buserelin, deslorelin, gonadorelin, goserelin, leuprorelin, nafarelin and triptorelin, in males; 2.2 Corticotrophins and their releasing factors, e.g. Corticorelin; 2.3 Growth Hormone (GH), its fragments and releasing factors, including, but not limited to: Growth Hormone fragments, e.g. AOD-9604 and hGH 176-191; Growth Hormone Releasing Hormone (GHRH) and its analogues, e.g. CJC-1293, CJC-1295, sermorelin and tesamorelin; Growth Hormone Secretagogues (GHS), e.g. ghrelin and ghrelin mimetics, e.g. anamorelin, ipamorelin and tabimorelin; GH-Releasing Peptides (GHRPs), e.g. alexamorelin, GHRP-1, GHRP-2 (pralmorelin), GHRP-3, GHRP-4, GHRP-5, GHRP-6, and hexarelin. 3. Growth Factors and Growth Factor Modulators, including, but not limited to: Fibroblast Growth Factors (FGFs); Hepatocyte Growth Factor (HGF); Insulin-like Growth Factor-1 (IGF-1) and its analogues; Mechano Growth Factors (MGFs); Platelet-Derived Growth Factor (PDGF); Thymosin-β4 and its derivatives e.g. TB-500; Vascular-Endothelial Growth Factor (VEGF). Additional growth factors or growth factor modulators affecting muscle, tendon or ligament protein synthesis/ degradation, vascularisation, energy utilization, regenerative capacity or fibre type switching. BETA-2 AGONISTS All selective and non-selective beta-2 agonists, including all optical isomers, are prohibited. Including, but not limited to: Fenoterol; Formoterol; Higenamine; Indacaterol; Olodaterol; Procaterol; Reproterol; Salbutamol; Salmeterol; Terbutaline; Tulobuterol; Vilanterol. Except: • Inhaled salbutamol: maximum 1600 micrograms over 24 hours in divided doses not to exceed 800 micrograms over 12 hours starting from any dose; • Inhaled formoterol: maximum delivered dose of 54 micrograms over 24 hours; • Inhaled salmeterol: maximum 200 micrograms over 24 hours. The presence in urine of salbutamol in excess of 1000 ng/mL or formoterol in excess of 40 ng/mL is not consistent with therapeutic use of the substance and will be considered as an Adverse Analytical Finding (AAF) unless the Athlete proves, through a controlled pharmacokinetic study, that the abnormal result was the consequence of a therapeutic dose (by inhalation) up to the maximum dose indicated above. HORMONE AND METABOLIC MODULATORS The following hormone and metabolic modulators are prohibited: 1. Aromatase inhibitors including, but not limited to: 4-Androstene-3,6,17 trione (6-oxo); Aminoglutethimide; Anastrozole; Androsta-1,4,6-triene-3,17-dione (androstatrienedione); S3 S4 5 Androsta-3,5-diene-7,17-dione (arimistane); Exemestane; Formestane; Letrozole; Testolactone. 2. Selective estrogen receptor modulators (SERMs) including, but not limited to: Raloxifene; Tamoxifen; Toremifene. 3. Other anti-estrogenic substances including, but not limited to: Clomifene; Cyclofenil; Fulvestrant. 4. Agents modifying myostatin function(s) including, but not limited, to: myostatin inhibitors. 5. Metabolic modulators: 5.1 Activators of the AMP-activated protein kinase (AMPK), e.g. AICAR, SR9009; and Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists, e.g. 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl) phenyl)thiazol-5-yl)methylthio)phenoxy) acetic acid (GW1516, GW501516); 5.2 Insulins and insulin-mimetics; 5.3 Meldonium; 5.4 Trimetazidine. DIURETICS AND MASKING AGENTS The following diuretics and masking agents are prohibited, as are other substances with a similar chemical structure or similar biological effect(s). Including, but not limited to: • Desmopressin; probenecid; plasma expanders, e.g. intravenous administration of albumin, dextran, hydroxyethyl starch and mannitol. • Acetazolamide; amiloride; bumetanide; canrenone; chlortalidone; etacrynic acid; furosemide; indapamide; metolazone; spironolactone; thiazides, e.g. bendroflu- methiazide, chlorothiazide and hydrochlorothiazide; triamterene and vaptans, e.g. tolvaptan. S5 Except: • Drospirenone; pamabrom; and ophthalmic use of carbonic anhydrase inhibitors (e.g. dorzolamide, brinzolamide); • Local administration of felypressin in dental anaesthesia. The detection in an Athlete’s Sample at all times or In-Competition, as applicable, of any quantity of the following substances subject to threshold limits: formoterol, salbutamol, cathine, ephedrine, methylephedrine and pseudoephedrine, in conjunction with a diuretic or masking agent, will be considered as an Adverse Analytical Finding (AAF) unless the Athlete has an approved Therapeutic Use Exemption (TUE) for that substance in addition to the one granted for the diuretic or masking agent. 6 PROHIBITED METHODS MANIPULATION OF BLOOD AND BLOOD COMPONENTS The following are prohibited: 1. The Administration or reintroduction of any quantity of autologous, allogenic (homologous) or heterologous blood, or red blood cell products of any origin into the circulatory system. 2. Artificially enhancing the uptake, transport or delivery of oxygen. Including, but not limited to: Perfluorochemicals; efaproxiral (RSR13) and modified haemoglobin products, e.g. haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen by inhalation. 3. Any form of intravascular manipulation of the blood or blood components by physical or chemical means. CHEMICAL AND PHYSICAL MANIPULATION The following are prohibited: 1. Tampering, or Attempting to Tamper, to alter the integrity and validity of Samples collected during Doping Control. Including, but not limited to: Urine substitution and/or adulteration, e.g. proteases. 2. Intravenous infusions and/or injections of more than a total of 100 mL per 12 hour period except for those legitimately received in the course of hospital treatments, surgical procedures or clinical diagnostic investigations. M1 M2 GENE DOPING The following, with the potential to enhance sport performance, are prohibited: 1. The use of polymers of nucleic acids or nucleic acid analogues. 2. The use of gene editing agents designed to alter genome sequences and/or the transcriptional or epigenetic regulation of gene expression. 3. The use of normal or genetically modified cells. M3 7 IN ADDITION TO THE CATEGORIES S0 TO S5 AND M1 TO M3 DEFINED ABOVE, THE FOLLOWING CATEGORIES ARE PROHIBITED IN-COMPETITION: SUBSTANCES & METHODS PROHIBITED IN-COMPETITION PROHIBITED SUBSTANCES STIMULANTS All stimulants, including all optical isomers, e.g. d- and l- where relevant, are prohibited. Stimulants include: a: Non-Specified Stimulants: Adrafinil; Amfepramone; Amfetamine; Amfetaminil; Amiphenazole; Benfluorex; Benzylpiperazine; Bromantan; Clobenzorex; Cocaine; Cropropamide; Crotetamide; Fencamine; Fenetylline; Fenfluramine; Fenproporex; Fonturacetam [4-phenylpiracetam (carphedon)]; Furfenorex; Lisdexamfetamine; Mefenorex; Mephentermine; Mesocarb; Metamfetamine(d-); p-methylamphetamine; Modafinil; Norfenfluramine; Phendimetrazine; Phentermine; Prenylamine; Prolintane. A stimulant not expressly listed in this section is a Specified Substance. S6 b: Specified Stimulants. Including, but not limited to: 1,3-Dimethylbutylamine; 4-Methylhexan-2-amine (methylhexaneamine); Benzfetamine; Cathine**; Cathinone and its analogues, e.g. mephedrone, methedrone, and α - pyrrolidinovalerophenone; Dimethylamphetamine; Ephedrine***; Epinephrine**** (adrenaline); Etamivan; Etilamfetamine; Etilefrine; Famprofazone; Fenbutrazate; Fencamfamin; Heptaminol; Hydroxyamfetamine (parahydroxyamphetamine); Isometheptene; Levmetamfetamine; Meclofenoxate; Methylenedioxymethamphetamine; Methylephedrine***; Methylphenidate; Nikethamide; Norfenefrine; Octopamine; Oxilofrine (methylsynephrine); Pemoline; Pentetrazol; Phenethylamine and its derivatives; Phenmetrazine; Phenpromethamine; Propylhexedrine; Pseudoephedrine*****; 8 Selegiline; Sibutramine; Strychnine; Tenamfetamine (methylenedioxyamphetamine); Tuaminoheptane; and other substances with a similar chemical structure or similar biological effect(s). Except: • Clonidine; • Imidazole derivatives for topical/ophthalmic use and those stimulants included in the 2018 Monitoring Program*. * Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradrol, and synephrine: These substances are included in the 2018 Monitoring Program, and are not considered Prohibited Substances. ** Cathine: Prohibited when its concentration in urine is greater than 5 micrograms per milliliter. *** Ephedrine and methylephedrine: Prohibited when the concentration of either in urine is greater than 10 micrograms per milliliter. **** Epinephrine (adrenaline): Not prohibited in local administration, e.g. nasal, ophthalmologic, or co-administration with local anaesthetic agents. ***** Pseudoephedrine: Prohibited when its concentration in urine is greater than 150 micrograms per milliliter. NARCOTICS The following narcotics are prohibited: Buprenorphine; Dextromoramide; Diamorphine (heroin); Fentanyl and its derivatives; Hydromorphone; Methadone; Morphine; Nicomorphine; Oxycodone; Oxymorphone; Pentazocine; Pethidine. CANNABINOIDS The following cannabinoids are prohibited: • Natural cannabinoids, e.g. cannabis, hashish and marijuana, • Synthetic cannabinoids e.g. Δ9-tetrahydrocannabinol (THC) and other cannabimimetics. Except: • Cannabidiol. GLUCOCORTICOIDS All glucocorticoids are prohibited when administered by oral, intravenous, intramuscular or rectal routes. Including but not limited to: Betamethasone; Budesonide; Cortisone; Deflazacort; Dexamethasone; Fluticasone; Hydrocortisone; Methylprednisolone; Prednisolone; Prednisone; Triamcinolone. S7 S8 S9 9 SUBSTANCES PROHIBITED IN PARTICULAR SPORTS BETA-BLOCKERS Beta-blockers are prohibited In-Competition only, in the following sports, and also prohibited Out-of-Competition where indicated. • Archery (WA)* • Automobile (FIA) • Billiards (all disciplines) (WCBS) • Darts (WDF) • Golf (IGF) • Shooting (ISSF, IPC)* • Skiing/Snowboarding (FIS) in ski jumping, freestyle aerials/halfpipe and snowboard halfpipe/big air • Underwater sports (CMAS) in constant-weight apnoea with or without fins, dynamic apnoea with and without fins, free immersion apnoea, Jump Blue apnoea, spearfishing, static apnoea, target shooting, and variable weight apnoea. *Also prohibited Out-of-Competition Including, but not limited to: Acebutolol; Labetalol; Alprenolol; Levobunolol; Atenolol; Metipranolol; Betaxolol; Metoprolol; Bisoprolol; Nadolol; Bunolol; Oxprenolol; Carteolol; Pindolol; Carvedilol; Propranolol; Celiprolol; Sotalol; Esmolol; Timolol. P1 www.wada-ama.org

1 Prohibited Substances ANABOLIC AGENTS 1a Exogenous Anabolic Androgenic Steroids • 4-hydroxytestosterone was transferred to class S1.1b, “Endogenous Anabolic Androgenic Steroids (AAS)”, since this substance can be formed endogenously at low concentrations. • Bolandiol was removed, since it constitutes one of the isomers of 19-norandrostenediol, which is already included under class S1.1b. 1b Endogenous AAS and their Metabolites and isomers, when administered exogenously • The title of S1.1b “Endogenous Anabolic Androgenic Steroids when administered exogenously” was changed to: “Endogenous AAS and their Metabolites and isomers when administered exogenously” to clarify that ALL endogenous AAS and their Metabolites and isomers are prohibited when administered exogenously. Therefore, the listed examples now include the endogenous AAS and some of their Metabolites/isomers. • The examples of Metabolites and isomers of endogenous AAS were simplified, leaving only those endogenous substances that are currently known to be available in nutritional supplements or that may be used as masking agents (e.g. to affect the “steroid profile”). The currently named examples are: 7α-hydroxy-DHEA; 7β-hydroxy-DHEA; 4-androstenediol (androst-4-ene-3β,17β-diol); 5-androstenedione (androst-5-ene-3,17-dione); 7-keto-DHEA; epiandrosterone (3β-hydroxy-5α-androstan-17-one); epi-dihydrotestosterone (17β-hydroxy-5β-androstan- 3-one); epitestosterone. • All other substances previously listed as examples of Metabolites/isomers of endogenous AAS were removed S1 as specific examples of this class; however, such substances remain prohibited if administered exogenously. The Prohibited List usually does not list Metabolites, unless it provides useful information to either Athletes or stakeholders. The removed Metabolites may have multiple names and are not known to be available in nutritional supplements or to have biological activity. • The analysis of several of these Metabolites, as Markers of the exogenous administration of endogenous AAS is already covered in specific WADA Technical Documents: 19-Norandrosterone and 19-Noretiocholanolone are Metabolites of the 19-norsteroids, Nandrolone, 19-Norandrostenediol and 19-Norandrostenedione, and are covered in the TD19NA; Androsterone, Etiocholanolone, 5α-androstane- 3α,17β-diol (5αAdiol) and 5β-androstane-3α,17β-diol (5βAdiol), which are Metabolites of Testosterone and its precursors, are defined as Markers of the “steroid profile”, and are covered in the TDEAAS and TDIRMS; All the other substances previously listed (androstane- and androstenediols), if administered exogenously, are also monitored through GC/C/IRMS analysis of the Markers of the “steroid profile” (TDIRMS). • 2-Androstenone (5α-androst-2-ene-17-one) was transferred to class S4.1 Aromatase Inhibitors, which better reflects its biological activity. Analogues and isomers of this substance were also included in S4.1, namely 2-Androstenol (5α-androst-2-en-17-ol), 3-Androstenol (5α-androst-3-en-17-ol) and 3-Androstenone (5α-androst-3-en-17-one); • Epiandrosterone (3β-hydroxy-5α-androstan-17-one) was added as an example, since this substance is available in nutritional supplements. 2 Other Anabolic Agents: • Ostarine is now also listed by its International Non- proprietary Name (INN), enobosarm. SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES 2019 PROHIBITED LIST Substances and methods prohibited at all times (In- and Out-of-Competition) 2 PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES, AND MIMETICS • More examples of Hypoxia-inducible factor (HIF) activating agents were added. These are daprodustat (GSK1278863) and vadadustat (AKB-6548), while the reference name of molidustat, BAY 85-3934, has been included. • The title of S2.2 was changed to “Peptide Hormones and their Releasing Factors”, more accurately reflecting the substances in this class. • Ghrelin and hexarelin are now listed by their INNs, lenomorelin and examorelin, respectively. • Macimorelin was added as an example of a growth hormone secretagogue. BETA-2-AGONISTS • Tretoquinol (trimetoquinol) is a beta-2 agonist and was added as an example to S3. It is an ingredient in oral cold and flu medications, particularly in some countries in Asia. HORMONE AND METABOLIC MODULATORS • 2-Androstenone (5α-androst-2-ene-17-one) was transferred from S1.1b to this class, which better reflects its biological activity. Analogues and isomers of this substance were also included in S4.1, namely 2-Androstenol (5α-androst-2-en-17-ol), 3-Androstenol (5α-androst-3-en-17-ol) and 3-Androstenone (5α-androst-3-en-17-one). • The title of S4.4 was changed to: “Agents preventing Activin receptor IIB activation”, and several examples are listed. These include myostatin inhibitors such as myostatin-neutralizing antibodies (e.g. domagrozumab, landogrozumab, stamulumab), myostatin-binding proteins (e.g. follistatin, myostatin propeptide), agents reducing or ablating myostatin expression, activin receptor IIB competitors such as e.g. decoy activin receptors (e.g. ACE-031), anti-activin receptor IIB antibodies (e.g. bimagrumab), and activin A-neutralizing antibodies. This change was made to reflect the multiple ways in which this receptor can be affected. S2 S3 S4 Prohibited Methods GENE AND CELL DOPING • The title of this class was changed to: “Gene and Cell Doping”, in order to reflect that cells were already included in M3.3. Stem cells are not prohibited for treating injuries as long as their use restores normal function of the affected area and does not enhance function. The term “post-transcriptional” was added to the list of examples to more completely define the processes that can be modified by gene editing. Substances and Methods Prohibited In-Competition • The wording of the opening sentence was modified to harmonize with Article 4.2.2 of the Code as well as other sections of the List. In this regard, the word “categories” was replaced by “classes”. STIMULANTS • For consistency in chemical nomenclature, 1,3-dimethylbutylamine is also represented as 4-methylpentan-2-amine. Two additional analogues of methylhexaneamine were added as examples: 5-methylhexan-2-amine (1,4-dimethylpentylamine) and 3-methylhexan-2-amine (1,2-dimethylpentylamine). • Dimethylamphetamine is now listed by its INN dimetamfetamine. Other amphetamine compounds were standardized to align with the INN. M3 S6 3 Substances Prohibited in Particular Sports BETA-BLOCKERS • Bunolol is a racemic mixture of levobunolol and bunolol, so levobunolol was removed as an example in P1. * For further information on previous modifications and clarifications please consult the Prohibited List Q & A on www.wada-ama.org/en/questions-answers/prohibited-list- qa P1

1 Prohibited Substances ANABOLIC AGENTS 1a Exogenous Anabolic Androgenic Steroids • 4-hydroxytestosterone was transferred to class S1.1b, “Endogenous Anabolic Androgenic Steroids (AAS)”, since this substance can be formed endogenously at low concentrations. • Bolandiol was removed, since it constitutes one of the isomers of 19-norandrostenediol, which is already included under class S1.1b. 1b Endogenous AAS and their Metabolites and isomers, when administered exogenously • The title of S1.1b “Endogenous Anabolic Androgenic Steroids when administered exogenously” was changed to: “Endogenous AAS and their Metabolites and isomers when administered exogenously” to clarify that ALL endogenous AAS and their Metabolites and isomers are prohibited when administered exogenously. Therefore, the listed examples now include the endogenous AAS and some of their Metabolites/isomers. • The examples of Metabolites and isomers of endogenous AAS were simplified, leaving only those endogenous substances that are currently known to be available in nutritional supplements or that may be used as masking agents (e.g. to affect the “steroid profile”). The currently named examples are: 7α-hydroxy-DHEA; 7β-hydroxy-DHEA; 4-androstenediol (androst-4-ene-3β,17β-diol); 5-androstenedione (androst-5-ene-3,17-dione); 7-keto-DHEA; epiandrosterone (3β-hydroxy-5α-androstan-17-one); epi-dihydrotestosterone (17β-hydroxy-5β-androstan- 3-one); epitestosterone. • All other substances previously listed as examples of Metabolites/isomers of endogenous AAS were removed S1 as specific examples of this class; however, such substances remain prohibited if administered exogenously. The Prohibited List usually does not list Metabolites, unless it provides useful information to either Athletes or stakeholders. The removed Metabolites may have multiple names and are not known to be available in nutritional supplements or to have biological activity. • The analysis of several of these Metabolites, as Markers of the exogenous administration of endogenous AAS is already covered in specific WADA Technical Documents: 19-Norandrosterone and 19-Noretiocholanolone are Metabolites of the 19-norsteroids, Nandrolone, 19-Norandrostenediol and 19-Norandrostenedione, and are covered in the TD19NA; Androsterone, Etiocholanolone, 5α-androstane- 3α,17β-diol (5αAdiol) and 5β-androstane-3α,17β-diol (5βAdiol), which are Metabolites of Testosterone and its precursors, are defined as Markers of the “steroid profile”, and are covered in the TDEAAS and TDIRMS; All the other substances previously listed (androstane- and androstenediols), if administered exogenously, are also monitored through GC/C/IRMS analysis of the Markers of the “steroid profile” (TDIRMS). • 2-Androstenone (5α-androst-2-ene-17-one) was transferred to class S4.1 Aromatase Inhibitors, which better reflects its biological activity. Analogues and isomers of this substance were also included in S4.1, namely 2-Androstenol (5α-androst-2-en-17-ol), 3-Androstenol (5α-androst-3-en-17-ol) and 3-Androstenone (5α-androst-3-en-17-one); • Epiandrosterone (3β-hydroxy-5α-androstan-17-one) was added as an example, since this substance is available in nutritional supplements. 2 Other Anabolic Agents: • Ostarine is now also listed by its International Non- proprietary Name (INN), enobosarm. SUMMARY OF MAJOR MODIFICATIONS AND EXPLANATORY NOTES 2019 PROHIBITED LIST Substances and methods prohibited at all times (In- and Out-of-Competition) 2 PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES, AND MIMETICS • More examples of Hypoxia-inducible factor (HIF) activating agents were added. These are daprodustat (GSK1278863) and vadadustat (AKB-6548), while the reference name of molidustat, BAY 85-3934, has been included. • The title of S2.2 was changed to “Peptide Hormones and their Releasing Factors”, more accurately reflecting the substances in this class. • Ghrelin and hexarelin are now listed by their INNs, lenomorelin and examorelin, respectively. • Macimorelin was added as an example of a growth hormone secretagogue. BETA-2-AGONISTS • Tretoquinol (trimetoquinol) is a beta-2 agonist and was added as an example to S3. It is an ingredient in oral cold and flu medications, particularly in some countries in Asia. HORMONE AND METABOLIC MODULATORS • 2-Androstenone (5α-androst-2-ene-17-one) was transferred from S1.1b to this class, which better reflects its biological activity. Analogues and isomers of this substance were also included in S4.1, namely 2-Androstenol (5α-androst-2-en-17-ol), 3-Androstenol (5α-androst-3-en-17-ol) and 3-Androstenone (5α-androst-3-en-17-one). • The title of S4.4 was changed to: “Agents preventing Activin receptor IIB activation”, and several examples are listed. These include myostatin inhibitors such as myostatin-neutralizing antibodies (e.g. domagrozumab, landogrozumab, stamulumab), myostatin-binding proteins (e.g. follistatin, myostatin propeptide), agents reducing or ablating myostatin expression, activin receptor IIB competitors such as e.g. decoy activin receptors (e.g. ACE-031), anti-activin receptor IIB antibodies (e.g. bimagrumab), and activin A-neutralizing antibodies. This change was made to reflect the multiple ways in which this receptor can be affected. S2 S3 S4 Prohibited Methods GENE AND CELL DOPING • The title of this class was changed to: “Gene and Cell Doping”, in order to reflect that cells were already included in M3.3. Stem cells are not prohibited for treating injuries as long as their use restores normal function of the affected area and does not enhance function. The term “post-transcriptional” was added to the list of examples to more completely define the processes that can be modified by gene editing. Substances and Methods Prohibited In-Competition • The wording of the opening sentence was modified to harmonize with Article 4.2.2 of the Code as well as other sections of the List. In this regard, the word “categories” was replaced by “classes”. STIMULANTS • For consistency in chemical nomenclature, 1,3-dimethylbutylamine is also represented as 4-methylpentan-2-amine. Two additional analogues of methylhexaneamine were added as examples: 5-methylhexan-2-amine (1,4-dimethylpentylamine) and 3-methylhexan-2-amine (1,2-dimethylpentylamine). • Dimethylamphetamine is now listed by its INN dimetamfetamine. Other amphetamine compounds were standardized to align with the INN. M3 S6 3 Substances Prohibited in Particular Sports BETA-BLOCKERS • Bunolol is a racemic mixture of levobunolol and bunolol, so levobunolol was removed as an example in P1. * For further information on previous modifications and clarifications please consult the Prohibited List Q & A on www.wada-ama.org/en/questions-answers/prohibited-list- qa P1